欧文誌上発表

Original Articles

  1. Muramatsu, T. A sulphated mucopolysaccharide from the jelly coat of starfish eggs. J. Biochem. 57, 223-225 (1965).
  2. Muramatsu, T., Egami, F. Hydrolysis of ovalbumin glycopeptide and ovomucoid glycopeptide by an enzyme preparation from the liver of Charonia lampas. Jap. J. Exp. Med. 35, 171-179 (1965).
  3. Muramatsu, T. Purification of α-D-mannosidase and β-D-mannosidase from marine gastropods. Arch. Biochem. Biophys. 115, 427-429 (1966).
  4. Muramatsu, T. Purification and properties of -mannosidase from the liver of Charonia lampas. J. Biochem. 62, 487-491 (1967).
  5. Muramatsu, T., Egami, F. α-Mannosidase and β-mannosidase from the liver of Turbo cornutus: purification, properties and application in carbohydrate research. J. Biochem. 62, 700-709 (1967).
  6. Fukuda, M., Muramatsu, T., Egami, F., Takahashi, N., Yasuda, Y. Purification of β-xylosidase and its action on O-β-xylosyl L-serine and stem bromelain glycopeptide. Biochim. Biophys. Acta 159, 215-216 (1968).
  7. Muramatsu, T. N-Acetylhexosaminidases from a gastropod, Turbo cornutus. J. Biochem. 64, 521-531 (1968).
  8. Fukuda, M., Muramatsu, T., Egami, F. β-xylosidase from the liver of Charonia lampas. I. Purification, properties and application in carbohydrate research. J. Biochem. 65, 191-199 (1969).
  9. Arima, T., Muramatsu, T., Saigo, K., Egami, F. Sialomucopolysaccharides from the bovine brain. Jap. J. Exp. Med. 39, 301-309 (1969).
  10. Muramatsu, T., Nathenson, S.G. Isolation of a chromatographically unique glycopeptide from murine histocompatibility-2 (H-2) membrane alloantigens labelled with H3-fucose or　H3-glucosamine. Biochem. Biophys. Res. Commun. 38, 1-8 (1970).
  11. Muramatsu, T., Nathenson, S.G. Studies on the carbohydrate portion of membrane-located mouse H-2 alloantigens. Biochemistry 9, 4875-4883 (1970).
  12. Muramatsu, T. Demonstration of an endo-glycosidase acting on a glycoprotein. J. Biol. Chem. 246, 5535-5537 (1971).
  13. Muramatsu, T., Nathenson, S.G. Comparison of the carbohydrate portion of membrane H-2 alloantigens isolated from spleen cells and tumor cells. Biochim. Biophys. Acta 241, 195-199 (1971).
  14. Iijima, Y., Muramatsu, T., Egami, F. Purification of -L-fucosidase from the liver of a marine gastropod, Turbo cornutus, and its action on blood group substances. Arch. Biochem. Biophys. 145, 50-54 (1971).
  15. Muramatsu, T., Atkinson, P.H., Nathenson, S.G., Ceccarini, C. Cell-surface glycopeptides: growth-dependent changes in the carbohydrate-peptide linkage region. J. Mol. Biol. 80, 781-799 (1973).
  16. Muramatsu, T., Nathenson, S.G., Boyse, E.A., Old, L.J., Some biochemical properties of thymus leukemia antigens solubilized from cell membranes by papain digestion. J. Exp. Med. 137, 1256-1262 (1973).
  17. Koide, N., Muramatsu, T. Endo--N-acetylglucosaminidase acting on carbohydrate moieties of glycoproteins: purification and properties of the enzyme from Diplococcus pneumoniae. J. Biol. Chem. 249, 4897-4904 (1974).
  18. Nishigaki, M., Muramatsu, T., Kobata, A., Maeyama, K. The broad aglycon specificity of α-L-fucosidase from marine gastropods. J. Biochem. 75, 509-517 (1974).
  19. Arakawa, M., Ogata, S., Muramatsu, T., Kobata, A., β-Galactosidases from jack bean and almond emulsin: application for the enzymatic distinction of Galβ1→4GlcNAc and Galβ1→3GlcNAc linkages. J. Biochem. 75, 707-714 (1974).
  20. Arakawa, M., Muramatsu, T. Endo-β-N-acetylglucosaminidases acting on the carbohydrate moieties of glycoproteins: the differential specificities of the enzymes from Streptomyces griseus and Diplococcus pneumoniae. J. Biochem. 76, 307-314 (1974).
  21. Nishigaki, M., Muramatsu, T., Kobata, A. Endoglycosidases acting on carbohydrate moieties of glycoproteins: demonstration in mammalian tissue. Biochem. Biophys. Res. Commun. 59, 638-645 (1974).
  22. Ito, S., Muramatsu, T., Kobata, A. Release of galactosyl oligosaccharides by endo-β-N-acetylglucosaminidase D. Biochem. Biophys. Res. Commun. 63, 938-944 (1975).
  23. Tai, T., Ito, S., Yamashita, K., Muramatsu, T., Kobata, A. Asparagine-linked oligosaccharide chains of IgG: a revised structure. Biochem. Biophys. Res. Commun. 65, 968-974 (1975).
  24. Koide, N., Muramatsu, T. Specific inhibition of endo-β-N-acetylglucosaminidase D by mannose and simple mannosides. Biochem. Biophys. Res. Commun. 66, 411-416 (1975).
  25. Muramatsu, T., Koide, N., Ogata-Arakawa, M. Analysis of oligomannosyl cores of cellular glycopeptides by digestion with endo-β-N-acetylglucosaminidases. Biochem. Biophys. Res. Commun. 66, 881-888 (1975).
  26. Ogata, S., Muramatsu, T., Kobata, A. Fractionation of glycopeptides by affinity column chromatography on concanavalin A-Sepharose. J. Biochem. 78, 687-696 (1975).
  27. Ito, S., Muramatsu, T., Kobata, A. Endo-β-N-acetylglucosaminidases acting on carbohydrate moieties of glycoproteins: purification and properties of the two enzymes with different specificities from Clostridium perfringens. Arch. Biochem. Biophys. 171, 78-86 (1975).
  28. Tai, T., Yamashita, K., Ogata-Arakawa, M., Koide, N., Muramatsu, T., Iwashita, S., Inoue, Y., Kobata, A. Structure of two ovalbumin glycopeptides in relation to endo-β-N-acetylglucosaminidase specificity. J. Biol. Chem. 250, 8569-8575 (1975).
  29. Ceccarini, C., Muramatsu, T., Tsang, J., Atkinson, P.H. Growth-dependent alterations in oligomannosyl cores of glycopeptides. Proc. Natl. Acad. Sci. USA 72, 3139-3143 (1975).
  30. Ogata, S., Muramatsu, T., Kobata, A. New structural characteristic of the large glycopeptides from transformed cells. Nature 259, 580-582 (1976).
  31. Muramatsu, T., Koide, N., Ceccarini, C., Atkinson, P.H. Characterization of mannose-labeled glycopeptides from human diploid cells and their growth-dependent alterations. J. Biol. Chem. 251, 4673-4679 (1976).
  32. Muramatsu, T., Ogata, M., Koide, N. Characterization of fucosyl glycopeptides from cell surface and cellular material of rat fibroblasts. Biochim. Biophys. Acta 444, 53-68 (1976).
  33. Ogata-Arakawa, M., Muramatsu, T., Kobata, A. Partial purification and characterization of an endo-β-N-acetylglucosaminidase from fig extract. J. Biochem. 82, 611-614 (1977).
  34. Ogata-Arakawa, M., Muramatsu, T., Kobata, A. α-L-Fucosidases from almond emulsin: characterization of the two enzymes with different specificities. Arch. Biochem. Biophys. 181, 353-359 (1977).
  35. Koide, N., Nose, M., Muramatsu, T. Recognition of IgG by Fc receptor and complement: effects of glycosidase digestion. Biochem. Biophys. Res. Commun. 75, 838-843 (1977).
  36. Muramatsu, T., Koide, N., Maeyama, K. Further studies on endo-β-N-acetylglucosaminidase D. J. Biochem. 83, 363-370 (1978).
  37. Muramatsu, T., Gachelin, G., Nicolas, J.F., Condamine, H., Jakob, H., Jacob, F. Carbohydrate structure and cell differentiation: unique properties of fucosyl glycopeptides isolated from embryonal carcinoma cells. Proc. Natl. Acad. Sci. USA 75, 2315-2319 (1978).
  38. Koide, N., Muramatsu, T., Kobata, A. Studies on mannosyl glycopeptides from normal and transformed cells. J. Biochem. 85, 149-155 (1979).
  39. Muramatsu, T., Gachelin, G., Damonneville, M., Delarbre, C., Jacob, F. Cell surface carbohydrates of embryonal carcinoma cells: polysaccharidic side chains of F9 antigens and receptors to two lectins, FBP and PNA. Cell 18, 183-191 (1979).
  40. Prujansky-Jacobovits, A., Gachelin, G., Muramatsu, T., Sharon, N., Jacob, F. Surface galactosyl glycopeptides of embryonal carcinoma cells. Biochem. Biophys. Res. Commun. 89, 448-455 (1979).
  41. Muramatsu, T., Gachelin, G., Jacob, F. Characterization of glycopeptides from membranes of F9 embryonal carcinoma cells. Biochim. Biophys. Acta 587, 392-406 (1979).
  42. Muramatsu, T., Avner, P., Fellous, M., Gachelin, G., Jacob, F. Distinctive properties of fucosyl glycopeptides on human teratoma cells. Somatic Cell Genet. 5, 753-761 (1979).
  43. Muramatsu, T., Condamine, H., Gachelin, G., Jacob, F. Changes in fucosyl glycopeptides during early postimplantation embryogenesis in the mouse. J. Embryol. Exp. Morphol. 57, 25-36 (1980).
  44. Kasai, M., Ochiai, Y., Habu, S., Muramatsu, T., Tokunaga, T., Okumura, K. A new differentiation marker selectively expressed on mouse fetal thymocytes. Immunol. Lett. 2, 157-158 (1980).
  45. Muramatsu, T., Gachelin, G., Jacob, F. High-mannose glycopeptides from embryonal carcinoma cells. J. Biochem. 88, 685-688 (1980).
  46. Muramatsu, T., Muramatsu, H., Kasai, M., Habu, S., Okumura, K. Receptors for Dolichos biflorus agglutinin: new cell surface markers on a spontaneous leukemia. Biochem. Biophys. Res. Commun. 96, 1547-1553 (1980).
  47. Muramatsu, T., Muramatsu, H., Ozawa, M. Receptors for Dolichos biflorus agglutinin on embryonal carcinoma cells. J. Biochem. 89, 473-481 (1981).
  48. Watanabe, M., Muramatsu, T., Shirane, H., Ugai, K. Discrete distribution of binding sites for Dolichos biflorus agglutinin (DBA) and for peanut agglutinin (PNA) in mouse organ tissues. J. Histochem. Cytochem. 29, 779-790 (1981).
  49. Ozawa, M., Fujiyama, J., Furukawa, T., Sato, K., Noguchi, T., Muramatsu, T. Glycoproteins from teratocarcinomas and organs of adult mice: analysis by affinity chromatography on lectin-conjugated agarose. Dev. Growth Differ. 23, 515-522 (1981).
  50. Muramatsu, H., Muramatsu, T. Decreased synthesis of large fucosyl glycopeptides during differentiation of embryonal carcinoma cells induced by retinoic acid and dibutyryl cyclic AMP. Dev. Biol. 90, 441-444 (1982).
  51. Ozawa, M., Yonezawa, S., Sato, E., Muramatsu, T. A new glycoprotein antigen common to teratocarcinoma, visceral endoderm and renal tubular brush border. Dev. Biol. 91, 351-359 (1982).
  52. Ozawa, M., Yonezawa, S., Miyauchi, T., Sato, E., Muramatsu, T. New carbohydrate antigen found in large glycopeptides of teratocarcinoma cells. Biochem. Biophys. Res. Commun. 105, 495-501 (1982).
  53. Muramatsu, H., Muramatsu, T., Avner, P. Biochemical properties of the high-molecular-weight glycopeptides released from the cell surface of human teratocarcinoma cells. Cancer Res. 42, 1749-1752 (1982).
  54. Fujimoto, H., Muramatsu, T., Urushihara, H., Yanagisawa, K.O. Receptors to Dolichos biflorus agglutinin: a new cell surface marker common to teratocarcinoma cells and preimplantation mouse embryos. Differentiation 22, 59-61 (1982).
  55. Miyauchi, T., Yonezawa, S., Takamura, T., Chiba, T., Tejima, S., Ozawa, M., Sato, E., Muramatsu, T. A new fucosyl antigen expressed on colon adenocarcinoma and embryonal carcinoma cells. Nature 299, 168-169 (1982).
  56. Miyauchi, T., Muramatsu, H., Ozawa, M., Mizuta, T., Suzuki, T., Muramatsu, T. Receptors for peanut agglutinin isolated from cell lines of human Burkitt lymphoma, lung squamous cell carcinoma and gastric signet ring cell carcinoma. Gann 73, 581-587 (1982).
  57. Noguchi, M., Noguchi, T., Watanabe, M., Muramatsu, T. Localization of receptors for Dolichos biflorus agglutinin in early postimplantation embryos in mice. J. Embryol. Exp. Morphol. 72, 39-52 (1982).
  58. Murata, F., Tsuyama, S., Suzuki, S., Hamada, H., Ozawa, M., Muramatsu, T. Distribution of glycoconjugates in the kidney studied by use of labeled lectins. J. Histochem. Cytochem. 31, 139-144 (1983).
  59. Kawata, M., Higaki, K., Sekiya, S., Takamizawa, H., Muramatsu, T., Okumura, K. Antibodies to large glycopeptides in sera from patients with ovarian germ cell tumors. Clin. Exp. Immunol. 51, 401-406 (1983).
  60. Hamada, H., Sato, M., Murata, F., Muramatsu, T.Differential expression of lectin receptors in germ layers of the mouse egg cylinder and teratocarcinomas. Exp. Cell Res. 144, 489-495 (1983).
  61. Uehara, F., Sameshima, M., Muramatsu, T., Ohba, N. Localization of fluorescence-labeled lectin binding sites on photoreceptor cells of the monkey retina. Exp. Eye Res. 36, 113-123 (1983).
  62. Uehara, F., Muramatsu, T., Sameshima, M., Ogata, S., Ohba, N. Identification of peanut agglutinin receptors in the monkey retina. Exp. Eye Res. 37, 303-305 (1983).
  63. Kawamoto, Y., Muramatsu, T. Intracellular localization of the radioactive galactose incorporated into embryonal carcinoma cells. Cell Struct. Funct. 8, 85-87 (1983).
  64. Sato, M., Ogata, S., Ueda, R., Namikawa, R., Takahashi, T., Nakamura T., Sato, E., Muramatsu, T. Reactivity of a monoclonal antibody raised against human leukemic cells to embryonic and adult tissues of the mouse and teratocarcinomas. Dev. Growth Differ. 25, 333-344 (1983).
  65. Ozawa, M., Sato, M., Muramatsu, T. Basement membrane glycoprotein laminin is an agglutinin. J. Biochem. 94, 479-485 (1983).
  66. Muramatsu, H., Ishihara, H., Miyauchi, T., Gachelin, G., Fujisaki, T., Tejima, S., Muramatsu, T. Glycoprotein-bound large carbohydrates of early embryonic cells: structural characteristic of the glycan isolated from F9 embryonal carcinoma cells. J. Biochem. 94, 799-810 (1983).
  67. Ozawa, M., Higaki, K., Kawata, M., Sekiya, S., Takamizawa, H., Okumura, K., Muramatsu, T. An α-galactosyl residue in the large carbohydrates of teratocarcinoma cells: the antigenic determinant recognized by sera from patients with ovarian germ cell tumors. Biochem. Biophys. Res. Commun. 115, 268-274 (1983).
  68. Muramatsu, H., Muramatsu, T. A fucosyltransferase in teratocarcinoma stem cells: decreased activity after differentiation to parietal endoderm cells. FEBS Lett. 163, 181-184 (1983).
  69. Sato, M. Muramatsu, T., Berger, E. Immunological detection of cell surface galactosyltransferase in preimplantation mouse embryos. Dev. Biol. 102, 514-518 (1984).
  70. Fukuda, K., Matsuyama, H., Fukami, K., Ozawa, M., Muramatsu, T., Ohyama, M. Analysis of glycoproteins from nasal polyps and papillomas by affinity chromatography. Ann. Otol. Rhinol. Laryngol. 93, 85-88 (1984).
  71. Muramatsu, H., Muramatsu, T. Effects of succinyl concanavalin A and tunicamycin on F9 embryonal carcinoma cells: inhibition of cell spreading. Dev. Growth Differ. 26, 303-310 (1984).
  72. Noguchi, S., Ogata, S., Muramatsu, T. Stage-specific polypeptides in the developing mouse brain as demonstrated by two-dimensional gel electrophoresis. J. Biochem. 96, 881-886 (1984).
  73. Muramatsu, H., Miura, I., Gachelin, G., Tejima, S., Muramatsu, T. 1H-NMR spectroscopy of the glycoprotein-bound large carbohydrates from embryonal carcinoma cells. Biochem. Int. 9, 569-575 (1984).
  74. Hamada, H., Sato, M., Ozawa, M., Ohi, Y., Muramatsu, T. Transmembrane control of laminin, lectin receptors and surface villi in teratocarcinoma-derived endodermal cells. Exp. Cell Res. 154, 299-303 (1984).
  75. Ozawa, M., Muramatsu, T., Kemler, R. Molecular properties of ECMA 2 and ECMA 3 antigens defined by monoclonal antibodies against embryonal carcinoma cells. J. Biochem. 97, 307-315 (1985).
  76. Ozawa, M., Muramatsu, T. The glycoprotein-bound large carbohydrates from embryonal carcinoma cells carry receptors for several lectins recognizing N-acetylgalactosamine and galactose. J. Biochem. 97, 317-324 (1985).
  77. Ozawa, M., Muramatsu, T., Solter, D. SSEA-1, a stage-specific embryonic antigen of the mouse, is carried by the glycoprotein-bound large carbohydrate in embryonal carcinoma cells. Cell Differ. 16, 169-173 (1985).
  78. Arita, Y., Ogata, S., Ozawa, M., Muramatsu, T. Distinct properties of receptors for Dolichos biflorus agglutinin (DBA) isolated from small intestine of adult mice and endoderm cells of early embryos and teratocarcinomas. Differentiation 28, 254-259 (1985).
  79. Sato, M., Muramatsu, T. Reactivity of five N-acetylgalactosamine-recognizing lectins with preimplantation embryos, early postimplantation embryos, and teratocarcinoma cells of the mouse. Differentiation 29, 29-38 (1985).
  80. Muramatsu, H., Hamada, H., Noguchi, S., Kamada, Y., Muramatsu, T. Cell-surface changes during in vitro differentiation of pluripotent embryonal carcinoma cells. Dev. Biol. 110, 284-296 (1985).
  81. Ozawa, M., Sato, M., Muramatsu, H., Hamada, H., Muramatsu, T. A membrane glycoprotein involved in teratocarcinoma cell adhesion to substratum. Exp. Cell Res. 158, 127-143 (1985).
  82. Sato, M., Ozawa, M., Hamada, H., Kasai, M., Tokunaga, T., Muramatsu, T. Cell surface markers to monitor the process of visceral endoderm differentiation from embryonal carcinoma cells: identification of the stage sensitive to high concentration of retinoic acid. J. Embryol. Exp. Morphol. 88, 165-182 (1985).
  83. Uehara, F., Muramatsu, T., Sameshima, M., Kawano, K., Koide, H., Ohba, N. Effects of neuraminidase on lectin binding sites in photoreceptor cells of monkey retina. Jpn. J. Ophthalmol. 29, 54-62 (1985).
  84. Matsushita, Y., Yonezawa, S., Nakamura, T., Shimizu, S., Ozawa, M., Muramatsu, T., Sato, E. Carcinoma-specific Ulex europaeus agglutinin-I binding glycoproteins of human colorectal carcinoma and its relation to carcinoembryonic antigen. J. Natl. Cancer Inst. 75, 219-226 (1985).
  85. Noguchi, S., Ogata, S., Muramatsu, T. Altered synthesis of glucosamine-labeled glycopeptides during postimplantation embryogenesis of the mouse. Cell Differ. 16, 223-228 (1985).
  86. Ogata, S., Kamachi, Y., Arita, Y., Sato, M., Muramatsu, T. A re-examination of the isolectin components of the fucose-binding proteins of Lotus tetragonolobus. Carbohydr. Res. 144, 297-304 (1985).
  87. Nomoto, S., Muramatsu, H., Ozawa, M., Suganuma, T., Tashiro, M., Muramatsu, T. An anti-carbohydrate monoclonal antibody inhibits cell-substratum adhesion of F9 embryonal carcinoma cells. Exp. Cell Res. 164, 49-62 (1986).
  88. Sato, M., Yonezawa, S., Uehara, H., Arita, Y., Sato, E., Muramatsu, T. Differential distribution of receptors for two fucose-recognizing lectins in embryos and adult tissues of the mouse. Differentiation 30, 211-219 (1986).
  89. Sato, M., Muramatsu, T. Oncodevelopmental carbohydrate antigens: distribution of ECMA 2 and 3 antigens in embryonic and adult tissues of the mouse and in teratocarcinomas. J. Reprod. Immunol. 9, 123-135 (1986).
  90. Muramatsu, H., Kamada, Y., Muramatsu, T. Purification and properties of N-acetylglucosaminide α1→3 fucosyltransferase from embryonal carcinoma cells. Eur. J. Biochem. 157, 71-75 (1986).
  91. Uehara, F., Muramatsu, T., Ohba, N. Two-dimensional gel electrophoretic analysis of lectin receptors from the bovine interphotoreceptor matrix. Exp. Eye Res. 43, 227-234 (1986).
  92. Uehara, F., Sameshima, M., Muramatsu, T., Ohba, N. Affinity isolation of cone outer segments using a peanut agglutinin-nitrocellulose sheet. Exp. Eye Res. 43, 687-693 (1986).
  93. Uehara, F., Muramatsu, T., Ozawa, M., Koide, H., Sameshima, M., Ohba, N. Purification of antibody against peanut agglutinin receptors of bovine interphotoreceptor matrix. Jpn. J. Ophthalmol. 30, 56-62 (1986).
  94. Kawata, M., Sekiya, S., Takamizawa, H., Muramatsu, T., Okumura, K. Molecular properties of F9 embryoglycan recognized by a unique antibody in sera from patients with germ cell tumors. Cancer Res. 47, 2288-2294 (1987).
  95. Fushuku, N., Muramatsu, H., Uezono, M.M., Muramatsu, T. A new endo-β-galactosidase releasing Galαl→3Gal from carbohydrate moieties of glycoproteins and from a glycolipid. J. Biol. Chem. 262, 10086-10092 (1987).
  96. Kamada, Y., Arita, Y., Ogata, S., Muramatsu, H., Muramatsu, T. Receptors for fucose-binding proteins of Lotus tetragonolobus isolated from mouse embryonal carcinoma cells: structural characteristics of the poly(N-acetyllactosamine)-type glycan. Eur. J. Biochem. 163, 497-502 (1987).
  97. Shimoda, N., Muramatsu, H., Osawa, T., Yamada, T., Adachi, M., Muramatsu, T. Carbohydrate moieties of peanut agglutinin receptors isolated from human gastric cancer cells. J. Biochem. 102, 657-664 (1987).
  98. Suganuma, T., Muramatsu, H., Murata, F., Muramatsu, T. Purification and properties of N-acetylglucosaminide β1→4 galactosyltransferase from embryonal carcinoma cells. J. Biochem. 102, 665-671 (1987).
  99. Miyauchi, T., Yonezawa, S., Sato, E., Muramatsu, T. Preferential expression of glycolipids reacting with Ricinus Communis agglutinin-I in human colorectal adenocarcinomas. Biochem. Int. 15, 287-294 (1987).
  100. Ozawa, M., Yonezawa, S., Sato, M., Uehara, H., Sato, E., Muramatsu, T. Three groups of teratocarcinoma antigens co-expressed in the visceral endoderm are located in mutually exclusive sites in the adult kidney. Dev. Growth Differ. 29, 455-468 (1987).
  101. Noguchi, S., Muramatsu, T., Koike, T. Temporal increase of two proteins in PC-12 pheochromocytoma cells induced by nerve growth factor. Cell Struct. Funct. 12, 127-130 (1987).
  102. Sato, M., Muramatsu, T. Properties of smaller and larger cells from the 16-cell mouse embryo: increase in cell adhesiveness in the smaller cells cultured up to late 16-cell stage. Cell Struct. Funct. 12, 401-406 (1987).
  103. Yonezawa, S., Matsushita, Y., Muramatsu, H., Arita, Y., Nakamura, T., Muramatsu, T., Sato, E. Correlation between glycoconjugate expression and fucosyltransferase activity in human colorectal carcinoma. Acta Pathol. Jpn 37, 1249-1261 (1987).
  104. Ozawa, M., Huang, R.P., Furukawa, T., Muramatsu, T. A teratocarcinoma glycoprotein carrying a developmentally regulated carbohydrate marker is a member of the immunoglobulin gene superfamily. J. Biol. Chem. 263, 3059-3062 (1988).
  105. Kamada, Y., Muramatsu, H., Muramatsu, T., Kawata, M., Takamizawa, H. Glycopeptides from murine teratocarcinoma cells: structure of the determinants recognised by Griffonia simplicifolia agglutinin I and by sera from patients with ovarian germ cell tumors. Carbohydr. Res. 176, 237-243 (1988).
  106. Kadomatsu, K., Tomomura, M., Muramatsu, T. cDNA cloning and sequencing of a new gene intensely expressed in early differentiation stages of embryonal carcinoma cells and in mid-gestation period of mouse embryogenesis. Biochem. Biophys. Res. Commun. 151, 1312-1318 (1988).
  107. Kamada, Y., Muramatsu, H., Kawata, M., Takamizawa, H., Muramatsu, T. Poly-N-acetyllactosamines synthesized by cultured Ehrlich carcinoma cells: application of endo-β-galactosidase C for analysis of the terminal structure. J. Biochem. 104, 738-741 (1988).
  108. Yoshida, T., Muramatsu, H., Muramatsu, T., Sakamoto, H., Katoh, O., Sugimura, T., Terada, M. Differential expression of two homologous and clustered oncogenes, Hst1 and Int-2 during differentiation of F9 cells. Biochem. Biophys. Res. Commun. 157, 618-625 (1988).
  109. Kadomatsu, K., Huang, R.P., Suganuma, T., Murata, F., Muramatsu, T. A retinoic acid responsive gene MK found in the teratocarcinoma system is expressed in spatially and temporally controlled manner during mouse embryogenesis. J. Cell Biol. 110, 607-616 (1990).
  110. Miyauchi, T., Kanekura, T., Yamaoka, A., Ozawa, M., Miyazawa, S., Muramatsu, T. Basigin, a new, broadly distributed member of the immunoglobulin superfamily has strong homology with both the immunoglobulin V domain and the β-chain of major histocompatibility complex class II antigen. J. Biochem. 107, 316-323 (1990).
  111. Muramatsu, H., Muramatsu, T. Analysis of glycoprotein-bound carbohydrates from pluripotent embryonal carcinoma cells by pokeweed agglutinin-agarose. J. Biochem. 107, 629-634 (1990).
  112. Huang, R. P., Muramatsu, H., Muramatsu, T. Effects of different conditions of retinoic acid treatment on expression of MK gene, which is transiently activated during differentiation of embryonal carcinoma cells. Dev. Growth Differ. 32, 189-195 (1990).
  113. Furukawa, T., Ozawa, M., Huang, R. P., Muramatsu, T. A heparin binding protein whose expression increases during differentiation of embryonal carcinoma cells to parietal endoderm cells: cDNA cloning and sequence analysis. J. Biochem. 108, 297-302 (1990).
  114. Matsubara, S., Tomomura, M., Kadomatsu, K., Muramatsu, T. Structure of a retinoic acid-responsive gene, MK, which is transiently activated during the differentiation of embryonal carcinoma cells and the mid-gestation period of mouse embryogenesis. J. Biol. Chem. 265, 9441-9443 (1990).
  115. Tomomura, M., Kadomatsu, K., Matsubara, S., Muramatsu, T. A retinoic acid-responsive gene, MK, found in the teratocarcinoma system. Heterogeneity of the transcript and the nature of the translation product. J. Biol. Chem. 265, 10765-10770 (1990).
  116. Tomomura, M., Kadomatsu, K., Nakamoto, M., Muramatsu, H., Kondoh, H., Imagawa, K., Muramatsu, T. A retinoic acid responsive gene, MK, produces a secreted protein with heparin binding activity. Biochem. Biophys. Res. Commun. 171, 603-609 (1990).
  117. Huang, R.P., Ozawa, M., Kadomatsu, K., Muramatsu, T. Developmentally regulated expression of embigin, a member of the immunoglobulin superfamily found in embryonal carcinoma cells. Differentiation 45, 76-83 (1990).
  118. Kojima, S., Awaya, A., Ishido, M., Koyama, Y., Kubodera, A., Hashimoto, Y., Fukui, H., Muramatsu, H., Muramatsu, T. Radio-immunoimaging of tumors with radioactive antibody against a glycoprotein (GP 68) found in developing mouse brain. J. Cancer Res. Clin. Oncol. 116, 336-340 (1990).
  119. Unoki, K., Uehara, F., Muramatsu, T. Distribution of glycosyltransferase in bovine eyes. Ophtalmic Res. 22, 342-359 (1990).
  120. Unoki, K., Uehara, F., Muramatsu, T., Ohba, N. The effects of pyrimidine and purine nucleotides on sialyltransferase activity in bovine neurosensory retina. Jpn. J. Ophtalmol. 34, 409-413 (1990).
  121. Kanekura, T., Miyauchi, T., Tashiro, M., Muramatsu, T. Basigin, a new member of the immunoglobulin superfamily: genes in different mammalian species, glycosylation changes in the molecule from adult organs and possible variation in the N-terminal sequences. Cell Struct. Funct. 16, 23-30 (1991).
  122. Kamada, Y., Muramatsu, H., Arita, Y., Yamada, T., Muramatsu, T. Structural studies on a binding site for Dolichos biflorus agglutinin in the small intestine of the mouse. J. Biochem. 109, 178-183 (1991).
  123. Tsutsui, J., Uehara, K., Kadomatsu, K., Matsubara, S., Muramatsu, T. A new family of heparin-binding factors: strong conservation of midkine (MK) sequences between the human and the mouse. Biochem. Biophys. Res. Commun. 176, 792-797 (1991).
  124. Muramatsu, H., Muramatsu, T. Purification of recombinant midkine and examination of its biological activities: functional comparison of new heparin binding factors. Biochem. Biophys. Res. Commun. 177, 652-658 (1991).
  125. Miyauchi, T., Masuzawa, Y., Muramatsu, T. The basigin group of the immunoglobulin superfamily: complete conservation of a segment in and around transmembrane domains of human and mouse basigin and chicken HT7 antigen. J. Biochem. 110, 770-774 (1991).
  126. Suganuma, T., Muramatsu, H., Muramatsu, T., Ihida, K., Kawano, J., Murata, F. Subcellular localization of N-acetylglucosaminide β1→4 galactosyltransferase revealed by immunoelectron microscopy. J. Histochem. Cytochem. 39, 299-309 (1991).
  127. Yoshinaga, K., Muramatsu, H., Muramatsu, T. Immunohistochemical localization of the carbohydrate antigen 4C9 in the mouse embryo: a reliable marker of mouse primordial germ cells. Differentiation 48, 75-82 (1991).
  128. Matsusako, T., Muramatsu, H., Shirahama, T., Muramatsu, T., Ohi, Y. Expression of a carbohydrate signal, sialyl dimeric Lex antigen, is associated with metastatic potential of transitional cell carcinoma of the human urinary bladder. Biochem. Biophys. Res. Commun. 181, 1218-1222 (1991).
  129. Matsumoto, H., Muramatsu, H., Muramatsu, T., Shimazu, H. Carbohydrate profiles revealed by a lectin and a monoclonal antibody correlate with metastatic potential and prognosis of human lung carcinomas. Cancer 69, 2084-2090 (1992).
  130. Simon-Chazottes, D., Matsubara, S., Miyauchi, T., Muramatsu, T., Guenet, J.L. Chromosomal localization of two cell-surface associated molecules of potential importance in development: midkine (Mdk) and basigin (Bsg). Mamm. Genome 2, 269-271 (1992).
  131. Uehara, K., Matsubara, S., Kadomatsu, K., Tsutsui, J., Muramatsu, T. Genomic structure of human midkine (MK), a retinoic acid-responsive growth / differentiation factor. J. Biochem. 111, 563-567 (1992).
  132. Hokita, S., Takao, S., Muramatsu, T., Shimazu, H. Monoclonal antibodies against a human gastric cancer cell line with lung metastatic potential in nude mice define antigens whose expression is different between the primary and metastatic liver lesions. J. Cancer Res. Clin. Oncol. 118, 228-234 (1992).
  133. Shirahama, T., Ikoma, M., Muramatsu, H., Muramatsu, T., Ohi, Y. Reactivity to fucose-binding proteins of Lotus tetragonolobus correlates with metastatic phenotpye of transitional cell carcinoma of the bladder. J. Urol. 147, 1659-1664 (1992).
  134. Shirahama, T., Ikoma, M., Muramatsu, T., Ohi, Y. Expression of SSEA-1 carbohydrate antigen correlates with stage, grade and metastatic potential of transitional cell carcinoma of the bladder. J. Urol. 148, 1319-1322 (1992).
  135. Matsusako, T., Muramatsu, H., Shirahama, T., Muramatsu, T., Ohi, Y. A metastasis-associated antigen is present on a 60 kDa glycoprotein in transitional cell carcinoma of the human urinary bladder. Histochem. J. 24, 805-810 (1992).
  136. Nakamoto, M., Matsubara, S., Miyauchi, T., Obama, H., Ozawa, M., Muramatsu, T. A new family of heparin binding growth/differentiation factors: differential expression of the midkine (MK) and HB-GAM genes during mouse development. J. Biochem. 112, 346-349 (1992).
  137. Masuzawa, Y., Miyauchi, T., Hamanoue, M., Ando, S., Yoshida, J., Takao, S., Shimazu, H., Adachi, M., Muramatsu, T. A novel core protein as well as polymorphic epithelial mucin carry peanut agglutinin binding sites in human gastric carcinoma cells: sequence analysis and examination of gene expression. J. Biochem. 112, 609-615 (1992).
  138. Uehara, F., Ohba, N., Nakashima, Y., Yanagita, T., Ozawa, M., Muramatsu, T. Developmental change of distribution of β-galactoside α-2,6-sialyltransferase mRNA in rat retina. Exp. Eye Res. 56, 89-93 (1993).
  139. Ozawa, M., Muramatsu, T. Reticulocalbin, a novel endoplasmic reticulum resident Ca2+- binding protein with multiple EF-hand motifs and a carboxy-terminal HDEL sequence. J. Biol. Chem. 268, 699-705 (1993).
  140. Ohnishi, T., Nakamura, O., Ozawa, M., Arakai, N., Muramatsu, T., Daikuhara, Y. Molecular cloning and sequence analysis of cDNA for a 59 kD bone sialoprotein of the rat: demonstration that it is a counterpart of human α2-HS glycoprotein and bovine fetuin. J. Bone Miner. Res. 8, 367-377 (1993).
  141. Huang, R.-P., Ozawa, M., Kadomatsu, K., Muramatsu, T. Embigin, a member of the immunoglobulin superfamily expressed in embryonic cells, enhances cell-substratum adhesion. Dev. Biol. 155, 307-314 (1993).
  142. Maruta, H., Bartlett, P.F., Nurcombe, V., Nur-E-Kamal, M.S., Chomienne, C., Muramatsu, T., Muramatsu, H., Fabri, L., Nice, E., Burgess, A.W. Midkine (MK), a retinoic acid (RA)-inducible gene product, produced in E. coli acts on neuronal and HL60 leukemia cells. Growth Factors 8, 119-134 (1993).
  143. Tsutsui, J., Kadomatsu, K., Matsubara, S., Nakagawara, A., Hamanoue, M., Takao, S., Shimazu, H., Ohi, Y., Muramatsu, T. A new family of heparin-binding growth  differentiation factors: increased midkine expression in Wilms’ tumor and other human carcinomas. Cancer Res. 53, 1281-1285 (1993).
  144. Fabri, L., Maruta, H., Muramatsu, H., Muramatsu, T., Simpson, R.J., Burgess, A.W., Nice, E.C. Structural characterization of native and recombinant forms of the neurotrophic cytokine MK. J. Chromatog. 646, 213-225 (1993).
  145.  Kitamura, M., Shirasawa, T., Mitarai, T., Muramatsu, T., Maruyama, N. A retinoid responsive cytokine gene, MK, is preferentially expressed in the proximal tubules of the kidney and human tumor cell lines. Am. J. Pathol. 142, 425-431 (1993).
  146. Matsumoto, H., Muramatsu, H., Shimotakahara, T., Nishijima, H., Mitani, N., Baba, K., Muramatsu, T., Shimazu, H. Correlation of expression of ABH blood group carbohydrate antigens with metastatic potential in human lung carcinoma. Cancer 72, 75-81 (1993).
  147. Kaname, T., Kuwano, A., Murano, I., Uehara, K., Muramatsu, T., Kajii, T. Midkine gene (MDK), a gene for prenatal differentiation and neuroregulation, maps to band 11p11.2 by fluorescence in situ hybridization. Genomics 17, 514-515 (1993).
  148. Kaname, T., Miyauchi, T., Kuwano, A., Matsuda, Y., Muramatsu, T., Kajii, T. Mapping basigin (BSG), a member of the immunoglobulin superfamily, to 19p13.3. Cytogenet. Cell Genet. 64, 195-197 (1993).
  149. Michikawa, M., Kikuchi, S., Muramatsu, H., Muramatsu, T., Kim, S.U. Retinoic acid responsive gene product, midkine (MK), has neurotrophic functions for mouse spinal cord and dorsal root ganglion neurons in culture. J. Neurosci. Res. 35, 530-539 (1993).
  150. Uehara, F., Ohba, N., Nakashima, Y., Yanagita, T., Ozawa, M., Muramatsu, T. A fixative suitable for in situ hybridization histochemistry. J. Histochem. Cytochem. 41, 947-953 (1993).
  151. Yanagita, T., Uehara, F., Nakashima, Y., Ozawa, M., Muramatsu, T., Ohba, N. Demonstration of peripherin/rds mRNA in normal and light-damaged rat retinas by in situ hybridization histochemistry. Jpn. J. Ophtalmol. 37, 1-8 (1993).
  152. Uehara, F., Ohba, N., Nakashima, Y., Yanagita, T., Ozawa, M., Muramatsu, T. Distribution of peripherin/rds mRNA in cone-dominant squirrel retina. Exp. Eye Res. 56, 611-613 (1993).
  153. Yasuhara, O., Muramatsu, H., Kim, S.U., Muramatsu, T., Maruta, H., McGeer, P.L. Midkine, a novel neurotrophic factor, is present in senile plaques of Alzheimer disease. Biochem. Biophys. Res. Commun. 192, 246-251 (1993).
  154. Michikawa, M., Xu, R.Y., Muramatsu, H., Muramatsu, T., Kim, S.U. Midkine is a mediator of retinoic acid induced neuronal differentiation of embryonal carcinoma cells. Biochem. Biophys. Res. Commun. 192, 1312-1318 (1993).
  155. Satoh, J., Muramatsu, H., Moretto, G., Muramatsu, T., Chang, H.J., Kim, S.T., Cho, J.M., Kim, S.U. Midkine that promotes survival of human neurons is produced by fetal human astrocytes in culture. Dev. Brain Res. 75, 201-205 (1993).
  156. Muramatsu, H., Shirahama, H., Yonezawa, S., Maruta, H., Muramatsu, T. Midkine (MK), a retinoic acid-inducible growth/differentiation factor: immunochemical evidence for the function and distribution. Dev. Biol. 159, 392-402 (1993).
  157. Nakamoto, M., Ozawa, M., Jacinto, S.D., Furukawa, T., Natori, Y., Shirahama, H., Yonezawa, S., Nakayama, T., Muramatsu, T. Mouse heparin binding protein-44 (HBP-44) associates with brushin, a high molecular weight glycoprotein antigen common to the kidney and teratocarcinomas. J. Biochem. 114, 344-349 (1993).
  158. Shirahama, T., Ikoma, M., Muramatsu, T., Kayajima, T., Ohi, Y., Tsushima, T., Akebi, N.,  Ohmori, H., Hirao, Y., Okajima, E. The binding site for fucose-binding proteins of Lotus tetragonolobus is a prognostic marker for transitional cell carcinoma of the human urinary bladder. Cancer 72, 1329-1334 (1993).
  159. Kikuchi, S., Muramatsu, H., Muramatsu, T., Kim, S.U. Midkine, a novel neurotrophic factor, promotes survival of mesencephalic neurons in culture. Neurosci. Lett. 160, 9-12 (1993).
  160. Ikematsu, S., Kaname, T., Ozawa, M., Yonezawa, S., Sato, E., Uehara, F., Obama, H., Yamamura, K., Muramatsu, T. Transgenic mouse lines with ectopic expression of α-1,3-galactosyltransferase: production and characteristics. Glycobiology 3, 575-580 (1993).
  161. Unoki, K., Ohba, N., Arimura, H., Muramatsu, H., Muramatsu, T. Rescue of photoreceptors from the damaging effects of constant light by midkine, a retinoic acid responsive gene product. Invest. Ophthalmol. Vis. Sci. 35, 4063-4068 (1994).
  162. Obama, H., Matsubara, S., Guenet, J.L., Muramatsu, T. The midkine (MK) family of growth differentiation factors: structure of an MK-related sequence in a pseudogene and the evolutional relationships among members of the MK family. J. Biochem. 115, 516-522 (1994).
  163. Matsubara, S., Take, M., Pedraza, C., Muramatsu, T. Mapping and characterization of a retinoic acid-responsive enhancer of midkine, a novel heparin-binding growth / differentiation factor with neurotrophic activity. J. Biochem. 115, 1088-1096 (1994).
  164. Matsumoto, K., Wanaka, A., Takatsuji, K., Muramatsu, H., Muramatsu, T., Tohyama, M. A novel family of heparin-binding growth factors, pleiotrophin and midkine, is expressed in the developing rat cerebral cortex. Dev. Brain Res. 79, 229-241 (1994).
  165. Kaname, T., Matsubara, S., Murata, F., Yamamura, K., Miyata, K., Muramatsu, T. The upstream sequence of a new growth/differentiation factor, midkine (MK), mediates developmentally regulated lac Z gene expression in transgenic mice. Dev. Growth Differ. 36, 231-238 (1994).
  166. Muramatsu, H., Inui, T., Kimura, T., Sakakibara, S., Song, X., Murata, H., Muramatsu, T. Localization of heparin-binding, neurite outgrowth and antigenic regions in midkine molecule. Biochem. Biophys. Res. Commun. 203, 1131-1139 (1994).
  167. Take, M., Tsutsui, J., Obama, H., Ozawa, M., Nakayama, T., Maruyama, I., Arima, T., Muramatsu, T. Identification of nucleolin as a binding protein for midkine (MK) and heparin-binding growth-associated molecule (HB-GAM). J. Biochem. 116, 1063-1068 (1994).
  168. Matsumoto, K., Wanaka, A., Mori, T., Taguchi, A., Ishii, N., Muramatsu, H., Muramatsu, T., Tohyama, M. Localization of pleiotrophin and midkine in the postnatal developing cerebellum. Neurosci. Lett. 178, 216-220 (1994).
  169. Kojima, S., Inui, T., Kimura, T., Sakakibara, S., Muramatsu, H., Amanuma, H., Maruta, H., Muramatsu, T. Synthetic peptides derived from midkine enhances plasminogen activator in bovine aortic endothelial cells. Biochem. Biophys. Res. Commun. 206, 468-473 (1995).
  170. Yoshida, Y., Goto, M., Tsutsui, J., Ozawa, M., Sato, E., Osame, M., Muramatsu, T. Midkine is present in the early stage of cerebral infarct. Dev. Brain Res. 85, 25-30 (1995).
  171. Mitsiadis, T.A., Salmivirta, M., Muramatsu, T., Muramatsu, H., Rauvala, H., Lehtonen, E., Jalkanen, M., Thesleff, I. Expression of the heparin-binding cytokines, midkine (MK) and HB-GAM (pleiotrophin) is associated with epithelial-mesenchymal interactions during fetal development and organogenesis. Development, 121, 37-51 (1995).
  172. Mitsiadis, T.A., Muramatsu, T., Muramatsu, H., Thesleff, I. Midkine (MK), a heparin-binding growth/differentiation factor, is regulated by retinoic acid and epithelial-mesenchymal interactions in the developing mouse tooth, and affects cell proliferation and morphogenesis. J. Cell Biol. 129, 267-281 (1995).
  173. Sudou, A., Ozawa, M. and Muramatsu, T. Lewis X structure increases cell substratum adhesion in L cells. J. Biochem. 117, 271-275 (1995).
  174. Pedraza, C., Matsubara, S., Muramatsu, T. A retinoic acid-responsive element in human midkine gene. J. Biochem. 117, 845-849 (1995).
  175. Naved, A.F., Ozawa, M., Yu, S., Miyauchi, T., Muramatsu, H., Muramatsu, T. CBP-140, a novel endoplasmic reticulum resident Ca2+-binding protein with a carboxy terminal NDEL sequence showed partial homology with 70 kDa heat shock protein (hsp 70). Cell Struct. Funct. 20, 133-141 (1995).
  176. Kojima, S., Muramatsu, H., Amanuma, H., Muramatsu, T. Midkine enhances fibrinolytic activity of bovine endothelial cells. J. Biol. Chem. 270, 9590-9596 (1995).
  177.  Nakagawara, A., Milbrandt, J., Muramatsu, T., Deuel, T.F., Zhao, H., Cnaan, A., Brodeur, G.M. Differential expression of pleiotrophin and midkine in advanced neuroblastomas. Cancer Res. 55, 1792-1797 (1995).
  178. Aridome, K., Tsutsui, J., Takao, S., Kadomatsu, K., Ozawa, M., Aikou, T., Muramatsu, T. Increased midkine gene expression in human gastrointestinal cancers. Jpn. J. Cancer Res. 86, 655-661 (1995).
  179. Obama, H., Tsutsui, J., Ozawa, M., Yoshida, H., Yoshida, Y., Osame, M., Muramatsu, T. Midkine (MK) and pleiotrophin (PTN) expression in extraembryonic tissues, amniotic fluid and cerebrospinal fluid during mouse embryogenesis. J. Biochem. 118, 88-93 (1995).
  180. Sekiguchi, K., Yokota, C., Asashima, M., Kaname, T., Fan, Q.-W., Muramatsu, T., Kadomatsu, K. Restricted expression of Xenopus midkine gene during early development. J. Biochem. 118, 94-100 (1995).
  181. Yu. S., Ozawa, M., Naved, A.F., Miyauchi, T., Muramatsu, H., Muramatsu, T. cDNA cloning and sequence analysis of a novel calcium binding protein with oligoproline motif. Cell Struct. Funct. 20, 263-268 (1995).
  182. Masuda, K., Watanabe, I., Unoki, K., Ohba, N., Muramatsu, T. Functional rescue of photoreceptors from the damaging effects of constant light by survival-promoting factors in the rat. Invest. Ophthalmol. Vis. Sci. 36, 2142-2146 (1995).
  183. Obama, H., Kaname, T., Sudou, A., Yanagida, T., Ikematsu, S., Ozawa, M., Yoshida, H., Kannagi, R., Yamamura, K., Muramatsu, T. A transgenic mouse line with α-1,3/4 fucosyltransferase cDNA: production and characteristics. Glycoconj. J. 12, 795-801 (1995).
  184. Miyauchi, T., Jimma, F., Igakura, T., Yu, S., Ozawa, M., Muramatsu, T. Structure of the mouse basigin gene, a unique member of the immunoglobulin superfamily. J. Biochem. 118, 717-724 (1995).
  185. Kojima, S., Inui, T., Muramatsu, H., Kimura, T., Sakakibara, S., Muramatsu, T. Midkine is a heat and acid stable polypeptide capable of enhancing plasminogen activator activity and neurite outgrowth extension. Biochem. Biophys. Res. Commun. 216, 574-581 (1995).
  186. Uehara, F., Ozawa, M., Sameshima, M., Unoki, K., Okubo, A., Yanagita, T. Sugata, M., Iwakiri, N., Maeda, Y., Muramatsu, T., Ohba, N. Differential expression of mRNA for α-2,3-sialyltransferase during development of rat retina. Jpn. J. Ophthalmol. 39, 248-253 (1995).
  187. Inui, T., Bodi, J., Kubo, S., Nishio, H., Kimura, T., Kojima, S., Maruta, H., Muramatsu, T., Sakakibara, S. Solution synthesis of human midkine, a novel heparin binding neurotrophic factor consisting of 121 amino acid residues with five disulphide bonds. J. Pept. Sci. 2, 28-39 (1996).
  188. Ozawa, M., Muramatsu, T. Molecular cloning and expression of a mouse α-1, 3 fucosyltransferase gene that shows homology with the human α-1, 3 fucosyltransferase IV gene. J. Biochem. 119, 302-308 (1996).
  189. Kojima, T., Katsumi, A., Yamazaki, T., Muramatsu, T., Nagasaka, T., Ohsumi, K., Saito, H. Human ryudocan from endothelial-like cells binds basic fibroblast growth factor, midkine, and tissue factor pathway inhibitor. J. Biol. Chem. 271, 5914-5920 (1996).
  190.  Kaname, T., Kadomatsu, K., Aridome, K., Yamashita, S., Sakamoto, K., Ogawa, M., Muramatsu, T., Yamamura, K. The expression of truncated MK in human tumors. Biochem. Biophys. Res. Commun. 219, 256-260 (1996).
  191. Koike, C., Kannagi, R., Takuma, Y., Akutsu, F., Hayashi, S., Hiraiwa, N., Kadomatsu, K., Muramatsu, T., Yamakawa, H., Nagai, T., Kobayashi, S., Okada, H., Nakashima, I., Uchida, K., Yokoyama, I., Takagi, H. Introduction of α(1, 2)-fucosyltransferase and its effect on ?-Gal epitopes in transgenic pig. Xenotransplantation 3, 81-86 (1996).
  192. Kaneda, N., Talukder, A.H., Ishihara, M., Hara, S., Yoshida, K., Muramatsu, T. Structural characteristics of heparin-like domain required for interaction of midkine with embryonic neurons. Biochem. Biophys. Res. Commun. 220, 108-112 (1996).
  193. Kaneda, N., Talukder, A.H., Nishiyama, H., Koizumi, S., Muramatsu, T. Midkine, a heparin-binding growth / differentiation factor, exhibits nerve cell adhesion and guidance activity for neurite outgrowth in vitro. J. Biochem. 119, 1150-1156 (1996).
  194. Muramatsu, H., Song, X., Koide, N., Hada, H., Tsuji, T., Kadomatsu, K., Inui, T., Kimura, T., Sakakibara, S., Muramatsu, T. Enzyme-linked immunoassay for midkine, and its application to evaluation of midkine levels in developing mouse brain and sera from patients with hepatocellular carcinomas. J. Biochem. 119, 1171-1175 (1996).
  195. Miyashiro, I., Kaname, T., Nakayama, T., Nakamori, S., Yagyu, T., Monden, T., Kikkawa, N., Nishisho, I., Muramatsu, T., Monden, M., Akiyama, T. Expression of truncated midkine in human colorectal cancers. Cancer Lett. 106, 287-291 (1996).
  196. Igakura, T., Kadomatsu, K., Taguchi, O., Muramatsu, H., Kaname, T., Miyauchi, T., Yamamura, K., Arimura, K., Muramatsu, T. Roles of basigin, a member of the immunoglobulin superfamily, in bahavior as to an irritating odor, lymphocyte response and blood brain barrier. Biochem. Biophys. Res. Common. 224, 33-36 (1996).
  197. Adachi, Y., Matsubara, S., Pedraza, C., Ozawa, M., Tsutsui, J., Takamatsu, H., Noguchi, H., Akiyama, T., Muramatsu, T. Midkine as a novel target gene for the Wilms’ tumor suppressor gene (WT1). Oncogene, 13, 2197-2203 (1996).
  198. Matsuda, Y., Talukder, A. H., Ishihara, M., Hara, S., Yoshida, K., Muramatsu, T., Kaneda, N. Limited proteolysis by chymotrypsin of midkine and inhibition by heparin binding. Biochem. Biophys. Res. Commun. 228, 176-181 (1996).
  199. Takemoto, M., Shirahama, T., Miyauchi, T., Matsusako, T., Kaneda, N., Muramatsu, H., Ozawa, M., Ohi, Y., Muramatsu, T. Metanestin, a glycoprotein with metastasis-associated expression in transitional cell carcinoma of the urinary bladder. Int. J. Cancer 74, 7-14 (1997).
  200. Kadomatsu, K., Hagihara, M., Akhter, S., Fan, Q-W., Muramatsu, H., Muramatsu, T. Midkine induces the transformation of NIH3T3 cells. Br. J. Cancer 75, 354-359 (1997).
  201. Miyashiro, I., Kaname, T., Shin, E., Wakasugi, E., Monden, T., Takatsuka, Y., Kikkawa, N., Muramatsu, T., Monden, M., Akiyama, T. Midkine expression in human breast cancers: Expression of truncated form. Breast Cancer Res. Treat. 43, 1-6 (1997).
  202. Nakanishi, T., Kadomatsu, K., Okamoto, T., Ichihara-Tanaka, K., Kojima, T., Saito, H., Tomoda, Y., Muramatsu, T. Expression of syndecan-1 and -3 during embryogenesis of the central nervous system in relation to binding with midkine. J. Biochem. 121, 197-205 (1997).
  203. Toriyama, K., Muramatsu, H., Hoshino, T., Torii, S., Muramatsu, T. Evaluation of heparin-binding growth factors in rescueing morphogenesis of heparitinase-treated mouse embryonic lung explants. Differentiation 61, 161-167 (1997).
  204. Kojima, S., Inui, T., Muramatsu, H., Suzuki, Y., Kadomatsu, K., Yoshizawa, M., Hirose, S., Kimura, T., Sakakibara, S., Muramatsu, T. Dimerization of midkine by tissue transglutaminase and its functional implication. J. Biol. Chem. 272, 9410-9416 (1997).
  205. Uehara, K., Muramatsu, T. Molecular cloning and characterization of b-1, 4-galactosyltransferase expressed in mouse testis. Eur. J. Biochem. 244, 706-712 (1997).
  206. Sudou, A., Muramatsu, H., Kaname, T., Kadomatsu, K., Muramatsu, T. Lex structure enhances myocardial differentiation from embryonic stem cells. Cell Struct. Funct. 22, 247-251 (1997).
  207. Takada, T., Toriyama, K., Muramatsu, H., Song, X.-J., Torii, S., Muramatsu, T. Midkine, a retinoic acid-inducible heparin-binding cytokine in inflammatory responses: chemotactic activity to neutrophils and association with inflammatory synovitis. J. Biochem. 122, 453-458 (1997).
  208. Talukder, A.H., Muramatsu, T., Kaneda, N. A novel truncated variant form of Ebk/MDK1 receptor tyrosine kinase is expressed in embryonic mouse brain. Cell Struct. Funct. 22, 477-485 (1997).
  209. Nagasaka, T., Kobayashi, T., Muramatsu, H., Fujimoto, H., Matsuo, I., Ajisaka, K., Kadomatsu, K., Hayashi, S., Yokoyama, I., Hayakawa, A., Muramatsu, T., Takagi, H. ?-Galactosyl oligosaccharides conjugated with polyethylene glycol as potential inhibitors of hyperacute rejection upon xenotransplantation. Biochem. Biophys. Res. Common. 232, 731-736 (1997).
  210. Asai, T., Watanabe, K., Ichihara-Tanaka, K., Kaneda, N., Kojima, S., Iguchi, A., Inagaki, F., Muramatsu, T. Identification of heparin-binding sites in midkine and their role in neurite-promotion. Biochem. Biophys. Res. Commun. 236, 66-70 (1997).
  211. Inazumi, T., Tajima, S., Nishikawa, T., Kadomatsu, K., Muramatsu, H., Muramatsu, T. Expression of the retinoid-inducible polypeptide, midkine, in human epidermal keratinocytes. Arch. Deprmatol. Res. 289, 471-475 (1997).
  212.  Naruhashi, K., Kadomatsu, K., Igakura, T., Fan, Q.-W., Kuno, N., Muramatsu, H., Miyauchi, T., Hasegawa, T., Itoh, A., Muramatsu, T., Nabeshima, T. Abnormalities of sensory and memory functions in mice lacking Bsg gene. Biochem. Biophys. Res. Commun. 236, 733-737 (1997).
  213. Nakanishi, T., Kadomatsu, K., Okamoto, T., Tomoda, Y., Muramatsu, T. Expression of midkine and pleiotrophin in ovarian tumors. Obstet. Gynecol. 90, 285-290 (1997)
  214. Yamada, H., Inazumi, T., Tajima, S., Muramatsu, H., Muramatsu, T. Stimulation of collagen expression and glycosaminoglycan synthesis by midkine in human skin fibroblast. Arch. Dermatol. Res. 289, 429-433 (1997).
  215. Song, X-J., Muramatsu, H., Aridome, K., Aikou, T., Koide, N., Tsuji, T., Muramatsu, T. The serum level of midkine, a heparin-binding growth factor, as a tumor marker. Biomed. Res. 18, 375-381 (1997).
  216. Mishima, K., Asai, A., Kadomatsu, K., Ino, Y., Nomura, K., Narita, Y., Muramatsu, T., Kurino, T. Increased expression of midkine during the progression of human astrocytomas. Neurosci. Lett. 233, 29-32 (1997).
  217. Iwasaki, W., Nagata, K., Hatanaka, H., Inui, T., Kimura, T., Muramatsu, T., Yoshida, K., Tasumi, M., Inagaki, F. Solution structure of midkine, a new heparin-binding growth factor. EMBO J. 16, 6936-6946 (1997).
  218. Sun X.-Z., Inoue, M., Fukui, Y., Hisano, S., Sawada, K., Muramatsu, H., Muramatsu, T.  An immunohistochemical study of radial glial cells in the mouse brain prenatally exposed to ?-irradiation. J. Neuropathol. Exp. Neurol. 56, 1339-1348 (1997).
  219. Zhou, H., Muramatsu, T., Halfter, W., Tsim, K. W. K., Peng H. B. A role of midkine in the development of the neuromuscular junction. Mol. Cell. Neurosci. 10, 56-70 (1997).
  220. Koshizawa, S., Matsumura, T., Kadono, Y., Sawada, T., Kadomatsu, K., Muramatsu, H., Muramatsu, T. Alteration of midkine expression associated with chemically-induced differentiation in human neuroblastoma cells. Cancer Lett. 111, 117-125 (1997).
  221. Takada, T., Kinkori, T., Muramatsu, H., Hayakawa, A., Torri, S., Muramatsu, T. Midkine, a retinoic acid-inducible heparin-binding cytokine, is a novel regulator of intracellular calcium in human neutrophils. Biochem. Biophys. Res. Commun. 241, 756-761 (1997).
  222. Koike, C., Katayama, A., Kadomatsu, K., Muramatsu, T., Hiraiwa, N., Kanngaki, R., Nakashima, I., Yokoyama, I., Takagi, H. Direct gene replacement of the mouse  α(1,3)-galactosyltransferase gene with human  α(1,2)-fucosyltransferase gene: converting ?-galactosyl epitopes into H antigens. Xenotransplantation 4, 147-153 (1997).
  223. Haltia, A., Solin, M.L., Muramatu, T., Jalanko, H. Holmberg, C., Miettinen, A., Holthofer, H. Expression of nine developmental stage-specific genes in human kidney and cultured renal cells. Exp. Nephrol. 5, 457-464 (1997).
  224. Fan, Q-W., Yuasa, S., Kuno, N., Senda, T., Kobayashi, M., Muramatsu, T., Kadomatsu, K. Expression of basigin, a member of the immunoglobulin superfamily, in the mouse central nervous system. Neurosci. Res. 30, 53-63 (1998).
  225. Uchimura, K., Kadomatsu, K., Fan, Q.-W., Muramatsu, H., Kurosawa, N., Kaname, T., Yamamura, K., Fukuta, M., Habuchi, O., Muramatsu, T. Mouse chondroitin 6-sulfotransferase: molecular cloning, characterization and chromosomal mapping. Glycobiology 8, 489-496 (1998).
  226. Yokota, C., Takahashi, S., Eisaki, A., Asashima, M., Akhter, S., Muramatsu, T., Kadomatsu, K. Midkine counteracts the activin signal in mesoderm induction and promotes neural formation. J. Biochem. 123, 339-346 (1998).
  227. Igakura, T., Kadomatsu, K., Kaname, T., Muramatsu, H., Fan, Q.-W., Miyauchi, T., Toyama, Y., Kuno, N., Yuasa, S., Takahashi, M., Senda, M., Taguchi, O., Yamamura, K., Arimura, K., Muramatsu, T. A null mutation in basigin, an immunoglobulin superfamily member, indicates its important roles in peri-implantation development and spermatogenesis. Dev. Biol. 194, 152-165 (1998).
  228. Fan, Q.-W., Kadomatsu, K., Uchimura, K., Muramatsu, T. Embigin/basigin subgroup of the immunoglobulin superfamily: Different modes of expression during mouse embryogenesis and correlated expression with carbohydrate antigenic markers. Dev. Growth Differ. 40, 277-286 (1998).
  229.  Mochizuki, R., Takeda, A., Sato, N., Kimpara, T., Onodera, H., Itoyama, Y., Muramatsu, T. Induction of midkine expression in reactive astrocytes following rat transient forebrain ischemia. Exp. Neurol. 149, 73-78 (1998).
  230. Miyashiro, M., Kadomatsu, K., Ogata, N., Yamamoto, C., Takahashi, K., Uyama, M., Muramatsu, H., Muramatsu, T. Midkine expression in transient retinal ischemia in the rat. Curr. Eye Res. 17, 9-13(1998).
  231. Wang, S., Yoshida, Y., Goto, M., Moritoyo, T., Tsutsui, J., Izumo, S., Sato, E., Muramatsu, T., Osame, M. Midkine exists in astrocytes in the early stage of cerebral infarction. Dev. Brain Res. 106, 205-209 (1998).
  232. Obama, H., Biro, S., Tashiro, T., Biro, S., Tsutsui, J., Ozawa, M., Yoshida, H., Tanaka, H., Muramatsu, T. Myocardial infarction induces expression of midkine, a heparin-binding growth factor with reparative activity. Anticancer Res. 18, 145-152 (1998).
  233. Katayama, A., Ogawa, H., Kadomatsu, K., Kurosawa, N., Kobayashi, T., Kaneda, N., Uchimura, K., Yokoyama, I., Muramatsu, T., Takagi, H. Porcine α-1,3-galactosyltransferase: full length cDNA cloning, genomic organization, and analysis of splicing variants. Glycoconj. J. 15, 583-589 (1998).
  234.  Aridome, K., Takao, S., Kaname, T., Kadomatsu, K., Natsugoe, S., Kijima, F., Aikou, T., Muramatsu, T. Truncated midkine as a marker of diagnosis and detection of nodal metastases in gastrointestinal carcinomas. Br. J. Cancer 78, 472-477 (1998).
  235. Akhter, S., Ichihara-Tanaka, K., Kojima, S., Muramatsu, H., Inui, T., Kimura, T., Kaneda, N., Talukder, A. H., Kadomatsu, K., Inagaki, F., Muramatsu, T. Clusters of basic amino acids in midkine: roles in neurite-promoting activity and plasminogen activator-enhancing activity. J. Biochem. 123, 1127-1136 (1998).
  236. Kuno, N., Kadomatsu, K., Fan, Q.-W., Hagihara, M., Senda, T., Mizutani, S., Muramatsu, T. Female sterility in mice lacking the basigin gene, which encodes a transmembrane glycoprotein belonging to the immunoglobulin superfamily. FEBS Lett. 425, 191-194 (1998).
  237. Fujisawa, K., Matsumoto, Y., Muramatsu, H., Shinzato, T., Hiramatsu, K., Horie, K., Cai, Z., Oka, H., Amano, I., Muramatsu T., Maeda, K. Increased serum midkine levels during hemodialysis using heparin in chronic renal failure. J. Biochem. 123, 864-869 (1998).
  238. Uchimura, K., Muramatsu, H., Kadomatsu, K., Fan, Q.-W., Kurosawa, N., Mitsuoka, C., Kannagi, R., Habuchi, O., Muramatsu, T. Molecular cloning and characterization of an N-acetylglucosamine-6-O-sulfotransferase. J. Biol. Chem. 273, 22577-22583 (1998).
  239. Uchimura, K., Muramatsu, H., Kaname, T., Ogawa, H., Yamakawa, T., Fan, Q.-W., Mitsuoka, C., Kannagi, R., Habuchi, O., Yokoyama, I., Yamamura, K., Ozaki, T., Nakagawara, A., Kadomatsu, K., Muramatsu, T. Human N-acetylglucosamine-6-O-
    sulfotransferase involved in the biosynthesis of 6-sulfo sialyl Lewis X: molecular cloning,
    chromosomal mapping, and expression in various organs and tumor cells. J. Biochem. 124,  670-678 (1998).
  240. Taguchi, E., Muramatsu, H., Fan, Q.-W., Kurosawa, N., Sobue, G., Muramatsu, T. Zep: a novel zinc finger protein containing a large proline-rich domain. J. Biochem. 124, 1220-1228 (1998).
  241. Nakamura, E., Kadomatsu, K., Yuasa, S., Muramatsu, H., Mamiya, T., Nabeshima, T., Fan, Q.-W., Ishiguro, K., Igakura, T., Matsubara, S., Kaname, T., Horiba, M., Saito, H., Muramatsu, T. Disruption of the midkine gene (Mdk) resulted in altered expression of a calcium binding protein in the hippocampus of infant mice and their abnormal behaviour. Genes Cells 3, 811-822 (1998).
  242.  Maekawa, M., Suzuki-Toyota, F., Toyama, Y., Kadomatsu, K., Hagihara, M., Kuno, N., Muramatsu, T., Dohmae, K., Yuasa, S. Stage-specific localization of basigin, a member of the immunoglobulin suerfamily, during mouse spermatogenesis. Arch. Histol. Cytol. 61, 405-415 (1998).
  243. Wakisaka, S., Tabata, M.J., Maeda, T., Matsumoto, K., Wanaka, A., Muramatsu, H., Muramatsu, T., Kurisu, K. Immunohistochemical localization of pleiotrophin and midkine in the lingual epithelium of the adult rat. Arch. Histol. Cytol. 61, 475-480 (1998).
  244. Kimura, N., Mitsuoka, C., Kanamori, A., Hiraiwa, N., Uchimura, K., Muramatsu, T., Tamatani, T., Kansas, G.S., Kannagi, R. Reconstitution of functional L-selectin ligands on a cultured human endothelial cell line by cotransfection of α1→3 fucosyltransferase VII and newly cloned GlcNAcβ:6-sulfotransferase cDNA. Proc. Natl. Acad. Sci. USA 96, 4530-4535 (1999).
  245. Sakitani, H., Tsutsumi, M., Kadomatsu, K., Ikematsu, S., Takahama, M., Iki, K., Tsujiuchi, T., Muramatsu, T., Sakuma, S., Sakaki, T., Konishi, Y. Overexpression of midkine in lung tumors induced by N-nitrosobis-(2-hydroxypropyl)amine in rats and its increase with progression. Carcinogenesis 20, 465-469 (1999).
  246. Ye, C., Qi, M., Fan, Q.-W., Ito, K., Akiyama, S., Kasai, Y., Matsuyama, M., Muramatsu, T., Kadomatsu, K. Expression of midkine in the early stage of carcinogenesis in human colorectal cancer. Br. J. Cancer 79, 179-184 (1999).
  247. Yamakawa, T., Kurosawa, N., Kadomatsu, K., Matsui, T., Itoh, K., Maeda, N., Noda, M., Muramatsu, T. Levels of expression of pleiotrophin and protein tyrosine phosphatase ? are decreased in human colorectal cancers. Cancer Lett. 135, 91-96 (1999).
  248. Maeda, N., Ichihara-Tanaka, K., Kimura, T., Kadomatsu, K., Muramatsu, T., Noda, M. A receptor-like protein -tyrosine phosphatase PTPζ/RPTPβ binds a heparin-binding growth factor midkine. Involvement of arginine 78 of midkine in the high affinity binding to PTPζ. J. Biol. Chem. 274, 12474-12479 (1999).
  249. Fan, Q.-W., Uchimura, K., Yuzawa, Y., Matsuo, S., Mitsuoka, C., Kannagi, R., Muramatsu, H., Kadomatsu, K., Muramatsu, T. Spatially and temporally regulated expression of N-acetylglucosamine-6-O-sulfotransferase during mouse embryogenesis. Glycobiology 9, 947-955 (1999).
  250. Kuno, N., Kadomatsu, K., Muramatsu, T. Determination of the optimal time and dosage of all-trans retinoic acid for induction of murine exencephaly. Teratology 60, 63-67 (1999).
  251. Iwashita, N., Muramatsu, H., Toriyama, K., Torii, S., Muramatsu, T. Expression of midkine in normal and burn sites of rat skin. Burns 25, 119-124 (1999).
  252. Miyauchi, M., Shimada, H., Kadomatsu, K., Muramatsu, T., Matsubara, S., Ikematsu, S., Takenaga, K., Asano, T., Ochiai, T., Sakiyama, S., Tagawa, M. Frequent expression of midkine gene in esophageal cancer suggests a potential usage of its promoter for suicide gene therapy. Jpn. J. Cancer Res. 90, 469-475 (1999).
  253. Ohta, S., Muramatsu, H., Senda, T., Zou, K., Iwata, H., Muramatsu, T. Midkine is expressed during repair of bone fracture and promotes chondrogenesis. J. Bone Miner. Res. 14, 1132-1144 (1999).
  254. Matsuzawa, M., Muramatsu, T., Yamamori, T., Knoll, W., Yano, R. Novel neuronal effects of midkine on embryonic cerebellar neurons examined using a defined culture system. Cell. Mol. Neurobiol. 19, 209-221 (1999).
  255. Owada, K., Sanjyo, N., Kobayashi, T., Mizusawa, H., Muramatsu, H., Muramatsu, T., Michikawa, M. Midkine inhibits caspase-dependent apoptosis via the activation of mitogen-activated protein kinase and phosphatidylinositol 3-kinase in cultured neurons. J. Neurochem. 73, 2084-2092 (1999).
  256. Ishiguro, K., Kojima, T., Taguchi, O., Saito, H., Muramatsu, T., Kadomatsu, K. Syndecan-4 expression is associated with follicular atresia in mouse ovary. Histochem. Cell Biol. 112, 25-33 (1999).
  257. Konishi, N., Nakamura, M., Nakaoka, S., Hiasa, Y., Cho, M., Uemura, H., Hirao, Y., Muramatsu, T., Kadomatsu, K. Immunohistochemical analysis of midkine expression in human prostate carcinoma. Oncology 57, 253-257 (1999)
  258. Tachikui, H., Kurosawa, N., Kadomatsu, K., Muramatsu, T. Genomic organization and promoter activity of embigin, a member of the immunoglobulin superfamily. Gene 240, 325-332 (1999).
  259. Kurosawa, N., Kanemitsu, Y., Matsui, T., Shimada, K., Ishihama, H., Muramatsu, T.  Genomic analysis of a murine cell-surface sialomucin, MGC-24/CD164. Eur. J. Biochem. 265, 466-472 (1999).
  260.  Koide, N., Hada, H., Shinji, T., Ujike, K., Hirasaki, S., Yumoto, Y., Hanafusa, T., Kadomatsu, K., Muramatsu, H., Muramatsu, T., Tsuji, T. Expression of the midkine gene in human hepatocellular carcinomas. Hepatogastroenterology 46,3189-3196 (1999).
  261. Toyama, Y., Maekawa, M., Kadomatsu, K., Miyauchi, T., Muramatsu, T., Yuasa, S. Histological characterization of defective spermatogenesis in mice lacking the basigin gene. Anat. Histol. Embryol. 28, 205-213 (1999).
  262. Obama, H., Obama, K., Takemoto, M., Soejima, Y., Shirahama, T., Ohi, Y., Yoshida, H., Ozawa, M., Muramatsu, T., Maruyama, I. Expression of thrombomodulin in the epithelium of the urinary bladdar: a possible source of urinary thrombomodulin. Anticancer Res. 19, 1143-1147 (1999).
  263. Sumi, Y., Muramatsu, H., Hata, K., Ueda, M., Muramatsu, T. Midkine enhances early stages of collagen gel contraction. J. Biochem.127, 247-251 (2000).
  264. Qi, M., Ikematsu, S., Ichihara-Tanaka, K., Sakuma, S., Muramatsu, T., Kadomatsu, K. Midkine rescues Wilms’ tumor cells from cisplatin-induced apoptosis: regulation of Bcl-2 expression by midkine. J. Biochem. 127, 269-277 (2000).
  265. Fan, Q.-W., Muramatsu, T., Kadomatsu, K. Distinct expression of midkine and pleiotrophin in the spinal cord and placental tissues during early mouse development. Dev. Growth Differ. 42, 113-119 (2000).
  266. Kurosawa, N., Kadomatsu, K., Ikematsu, S., Sakuma, S., Kimura, T., Muramatsu, T.  Midkine binds specifically to sulfatide: the role of sulfatide in cell attachment to midkine-coated surfaces. Eur. J. Biochem. 267, 344-351 (2000).
  267.  Narita, M., Takanaga, K., Yoshida, Y., Kadomatsu, K., Muramatsu, T., Matsubara, S., Hamada,H., Goto, S., Saisho, H., Sakiyama, S., Tagawa, M. Polyadenylation signal facilitates the expression of foreign gene that is driven by an internal promoter located in the reverse orientation to long terminal repeat of retrovirus. Anticancer Res. 20, 279-282 (2000).
  268. Ishiguro, K., Kadomatsu, K., Kojima, T., Muramatsu, H., Tsuzuki, S., Nakamura, E., Kusugami, K., Saito, H., Muramatsu, T. Syndecan-4 deficiency impairs focal adhesion formation only under restricted conditions. J. Biol. Chem. 275, 5249-5252 (2000).
  269. Horiba, M., Kadomatsu, K., Nakamura, E., Muramatsu, H., Ikematsu, S., Sakuma, S., Hayashi, K., Yuzawa, Y., Matsuo, S., Kuzuya, M., Kaname, T., Hirai, M., Saito, H., Muramatsu, T. Neointima formation in a restenosis model is suppressed in midkine-deficient mice. J. Clin. Invest. 105, 489-495 (2000).
  270. Muramatsu, H., Zou, K., Sakaguchi, N., Ikematsu, S., Sakuma, S., Muramatsu, T. LDL-receptor related protein as a component of the midkine receptor. Biochem. Biophys. Res. Commun. 270, 936-941 (2000).
  271. Sumi, Y., Muramatsu, H., Hata, K.,Ueda, M., Muramatsu, T. Secretary leukocyte protease inhibitor is a novel inhibitor of fibroblast-mediated collagen gel contraction. Exp. Cell  Res. 256, 203-212 (2000).
  272. Matsui, T., Kurosawa, N., Hibi, K., Akiyama, S., Kasai, Y., Sakamoto, J., Ito, K., Nakao, A., Muramatsu, T. The ratio of splicing variant of MGC-24/CD164, a sialomucin, correlates with the metastatic potential of colorectal carcinomas. J. Biochem. 127, 1103-1107 (2000).
  273.  Zou, K., Muramatsu, H., Ikematsu, S., Sakuma, S., Salama, R.H., Shinomura, T., Kimata, K., Muramatsu, T. A heparin-binding growth factor, midkine, binds to a chondroitin sulfate proteoglycan, PG-M/versican. Eur. J. Biochem. 267, 4046-4053 (2000).
  274. Ogawa, H., Muramatsu, H., Kobayashi, T., Morozumi, K., Yokoyama, I., Kurosawa, N., Nakao, A., Muramatsu, T. Molecular cloning of endo-β-galactosidase C and its application in removing ?-galactosyl xenoantigen from blood vessels in the pig kidney. J. Biol. Chem. 275, 19368-19374 (2000).
  275. Chen, G., Kurosawa, N., Muramatsu, T. A novel variant form of murine β-1,6-N-acetylglucosaminyltransferase forming branches in poly-N-acetyllactosamines. Glycobiology 10, 1001-1011 (2000).
  276. Uchimura, K., Fasakhany, F., Kadomatsu, K., Matsukawa, T., Yamakawa, T., Kurasawa, N. , Muramatsu, T. Diversity of N-acetylglucosamine-6-O-sulfotransferases: molecular cloning of a novel enzyme with different distribution and specificities. Biochem. Biophys. Res. Commun. 274, 291-296 (2000).
  277. Kato, H., Watanabe, K., Murari, M., Isogai C., Kinoshita T., Nagai, H., Ohashi, H., Nagasaka, T., Kadomatsu, K., Muramatsu, H., Muramatsu, T., Saito, H., Mori, N., Murate, T. Midkine expression in Reed-Sternberg cells of Hodgkin’s disease. Leuk. Lymphoma 37, 415-424 (2000).
  278. Yoshida, S., Shibata, M., Yamamoto, S., Hagihara, M., Asai, N., Takahashi, M., Mizutani, S., Muramatsu, T., Kadomatsu, K. Homo-oligomer formation by basigin, an immunoglobulin superfamily member, via its N-terminal immunoglobulin domain. Eur. J. Biochem. 267, 4372-4380 (2000).
  279. Ikematsu, S., Yano, A., Aridome, K., Kikuchi, M., Kumai, H., Nagano, H., Okamoto, K., Oda, M., Sakuma, S., Aikou, T., Muramatsu, H., Kadomatsu, K., Muramatsu, T. Serum midkine levels are increased in patients with various types of carcinomas. Br. J. Cancer 83, 701-706 (2000).
  280. Ikeda, S., Nishikimi, A., Ichihara-Tanaka, K., Muramatsu, T., Yamada, M. cDNA cloning of bovine midkine and production of the recombinant protein, which affects in vitro maturation of bovine oocytes. Mol. Reprod. Dev. 57, 99-107 (2000).
  281.  Hori, K., Kitayama, N., Kachi, S., Kondo, M., Kadomatsu, K., Usukura, J., Muramatsu, T., Mori, S., Miyake, Y. Retinal dysfunction in basigin deficiency. Invest. Ophthalmol. Vis. Sci. 41, 3128-3133 (2000).
  282. Adachi, Y., Reynolds, P.N., Yamamoto, M., Grizzle W.E., Overturf, K., Matsubara, S., Muramatsu, T., Curiel, D.T. Midkine promoter-based adenoviral vector gene delivery for pediatric solid tumors. Cancer Res. 60, 4305-4310 (2000).
  283. Ishiguro, K., Kadomatsu, K., Kojima, T., Muramatsu, H., Nakamura, E., Ito, M., Nagasaka, T., Kobayashi, H., Kusugami, K., Saito, H., Muramatsu, T. Syndecan-4 deficiency impairs the fetal vessels in the placental labyrinth. Dev. Dyn. 219, 539-544 (2000).
  284. Ueoka, C., Kaneda, N., Okazaki, I., Nadanaka, S., Muramatsu, T., Sugahara, K. Neuronal cell adhesion mediated by the heparin-binding neuroregulatory factor midkine, is specifically inhibited by chondroitin sulfate E. Structural and functional implication of the oversulfated chondroitin sulfate. J. Biol. Chem. 275,37407-37413 (2000).
  285. Ikeda, S., Ichihara-Tanaka, K., Azuma, T., Muramatsu, T., Yamada, M. Effects of midkine during in vitro maturation of bovine oocytes on subsequent developmental competence. Biol. Reprod. 63, 1067-1074 (2000).
  286. Ishiguro, K., Kojima, T., Kadomatsu, K., Nakayama, Y., Takagi, A., Suzuki, M., Takeda, N., Ito, M., Yamamoto, K., Matsushita, T., Kusugami, K., Muramatsu, T., Saito, H. Complete antithrombin deficiency in mice results in embryonic lethality. J. Clin. Invest. 106, 873-878 (2000).
  287.  Tran, Q. K., Watanabe, H., Le, H.Y., Yang, J., Takeuchi, K., Kadomatsu, K., Muramatsu, T., Ohashi, K. Midkine inhibits bradykinin-stimulated Ca2+ signaling and nitric oxide production in endothelial cells. Biochem. Biophys. Res. Commun. 276, 830-836 (2000).
  288. Tsutsumi, M., Kadomatsu, K., Tsujiuchi, T., Sakitani, H., Ikematsu, S., Kubozoe, T., Yoshimoto, M., Muramatsu, T., Sakuma, S., Konishi, Y. Overexpression of midkine in pancreatic duct adenocarcinomas induced by N-nitrosobis (2-oxopropyl) amine in hamsters and their cell lines. Jpn. J. Cancer. Res. 91, 979-986 (2000).
  289.  Inui T., Nakao M., Nishio H., Nishiuchi, Y., Kojima S., Muramatsu, T., Kimura, T. Solution synthesis and biological activity of human pleiotrophin, a novel heparin-binding neurotrophic factor consisting of 136 amino acid residues with five disulfide bonds. J. Peptide Res. 55, 384-397 (2000).
  290. Qi, M., Ikematsu, S., Maeda, N., Ichihara-Tanaka, K., Sakuma, S., Noda, M., Muramatsu, T., Kadomatsu, K. Haptotactic migration induced by midkine: Involvement of protein-tyrosine phosphatase ?, mitogen-activated protein kinase and phosphatidylinositol 3-kinase. J. Biol. Chem. 276, 15868-15875 (2001).
  291. Ishiguro, K., Kadomatsu, K., Kojima, T., Muramatsu, H., Matsuo, S., Kusugami, K., Saito, H., Muramatsu, T. Syndecan-4 deficiency increases susceptibility to k-carrageenan-induced renal damage. Lab. Invest. 81, 509-516 (2001).
  292. Yoshida, Y., Ikematsu, S., Moritoyo, T., Goto, M., Tsutsui, J., Sakuma, S., Osame, M., Muramastu, T. Intraventricular administration of the neurotrophic factor midkine ameliorates hippocampal delayed neuronal death following transient forebrain ischemia in gerbils. Brain Res. 894, 46-55 (2001).
  293. Muramatsu, H., Tachikui, H., Ushida, H., Song X. J. Qiu, Y., Yamamoto, S., Muramatsu, T. Molecular cloning and expression of endo-β-N-acetylglucosaminidase D, which acts on the core structure of complex type asparagine-linked oligosaccharides. J. Biochem. 129, 923-928 (2001).
  294. El-Fasakhany, F.M., Uchimura, K., Kannagi, R., Muramatsu, T. A novel human Gal-3-O-sulfotransferase: cloning, characterization and its implications in biosynthesis of (SO4-3) Galβ1-4(Fucα1-3)GlcNAc. J. Biol. Chem. 276, 26988-26994 (2001).
  295. Ishihama, H., Ohbayashi, M., Kurosawa, N., Kitsukawa, T., Matsuura, O., Miyake, Y., Muramatsu, T. Colocalization of neuropilin-1 and Flk-1 in retinal neovascularization in a mouse model of retinopathy. Invest. Ophthalmol. Vis. Sci. 42, 1172-1178 (2001).
  296. Takahashi, A., Muramatsu, H., Takagi, S., Fujisawa, H., Miyake, Y., Muramatsu, T. A splicing factor, Prp8: preferential localization in the testis and ovary in adult mice. J. Biochem. 129, 599-606 (2001).
  297. Ochrietor J.D., Moroz, T.M., Kadomatsu, K, Muramatsu, T., Linser, P.J. Retinal degeneration following failed photoreceptor maturation in 5A11/basigin null mice. Exp. Eye Res. 467-477 (2001).
  298. Sato, W., Kadomatsu, K., Yuzawa, Y., Muramatsu, H., Hotta, N., Matsuo, S., Muramatsu T. Midkine is involved in neutrophil infiltration into the tubulointerstitium in ischemic renal injury. J. Immunol. 167, 3463-3469 (2001).
  299. Ishiguro, K., Kadomatsu, K., Kojima, T., Muramatsu, H., Iwase, M., Yoshikai, Y., Yanada, M., Yamamoto, K., Matsushita, T., Nishimura, M., Kusugami, K., Saito, H., Muramatsu, T. Syndecan-4 deficiency leads to high mortality of lipopolysaccharide-injected mice. J. Biol. Chem. 276, 47483-47488 (2001).
  300. Takei, Y., Kadomatsu, K., Matsuo, S., Itoh, H., Nakazawa, K., Kubota, S., Muramatsu, T. Antisense oligodeoxynucleotide targeted to midkine, a heparin-binding growth factor, suppresses tumorigenicity of mouse rectal carcinoma cells. Cancer Res. 61, 8486-8491 (2001).
  301. Rumsby, M., Ichihara-Tanaka, K., Kimura, T., Scott, M., Haynes, L., Muramatsu T. Bipolar undifferented CG-4 oligodendroglial line cells adhere, extend processes and disperse on midkine, a heparin-binding growth factor: orthovanadate and chondroitin sulfate E inhibit cell attachment. Neurosci. Res. Commun. 28, 31-39, (2001).
  302. Salama, R.H., Muramatsu, H., Zou, K., Inui, T., Kimura, T., Muramatsu, T.  Midkine binds to 37-kDa laminin binding protein precursor, leading to nuclear transport of the complex. Exp. Cell Res. 270,13-20 (2001).
  303. Jia, X.Q., Nakashima, T., Kadomatsu, K., Muramatsu, T. Expression of midkine in the cochlea. Hear. Res. 160,10-14 (2001).
  304. Chen, G., Kurosawa, N., Muramatsu, T. Functional analysis of promoter activity of murine  β-1,6-N-acetylglucosaminyltransferase. Gene 275, 253-259 (2001).
  305. Miyauchi, M., Yoshida, Y., Tada, Y., Narita, M., Maeda, T., Bahar, R., Kadomatsu, K., Muramatsu, T., Matsubara, S., Nakagawara, A., Sakiyama, S., Tagawa, M. Expression of herpes simplex virus-thymidine kinase gene controlled by a promoter region of the midkine gene confers selective cytotoxicity to ganciclovir in human carcinoma cells. Int. J. Cancer 91,723-727 (2001).
  306. Adachi, Y., Reynolds, P.N., Yamamoto, M., Wang, M., Takayama, K., Matsubara, S., Muramatsu, T., Curiel, D.T. A midkine promoter-based conditionally replicative adenovirus for treatment of pediatric solid tumors and bone marrow tumor purging. Cancer Res. 61,7882-7888 (2001).
  307. Hayashi, K., Kadomatsu, K., Muramatsu, T. Requirement of chondroitin sulfate/dermatan sulfate recognition in midkine-dependent migration of macrophages. Glycoconj. J. 18, 401-406 (2001).
  308. Kurosawa, N., Chen, G., Kadomatsu, K., Ikematsu, S., Sakuma S., Muramatsu, T.  Glypican-2 binds to midkine: the role of glypican-2 in neuronal cell adhesion and neurite outgrowth. Glycoconj. J. 18, 499-507(2001).
  309. Ogawa, H., Kobayashi, T., Yokoyama,I., Nagatani, N., Mizuno, M., Yoshida, J., Kadomatsu, K., Muramatsu, H., Nakao, A., Muramatsu, T. Reduction of α-galactosy xenoantigen by expression of endo-β-galactosidase C in pig endothelial cells. Xenotransplantation 9, 290-296 (2002).
  310. Uchimura, K., Kadomatsu, K., Nishimura, H., Muramatsu, H., Nakamura, E., Kurosawa, N., Habuchi, O., El-Fasakhany, F.M., Yoshikai, Y., Muramatsu, T. Functional analysis of the chondoroitin 6-sulfotransferase gene in relation to lymphocyte subpopulation, brain development, and oversulfated chondroitin sulfates. J. Biol. Chem. 277, 1443-1450(2002).
  311.  Liu, D., Kobayashi, T., Yokoyama, I., Ogawa, H., Nagasaka, T., Muramatsu, H., Kadomatsu, K., Oikawa, T., Shimano, Y., Morozumi, K., Uchida, K., Muramatsu, T., Nakao, A. Enzymatic removal of αGal antigen in pig kidneys by ex vivo and in vivo administration of endo-β-galactosidase C. Xenotransplantation 9, 228-236 (2002).
  312. Yanada, M., Kojima, T., Ishiguro, K., Nakayama, Y., Yamamoto, K., Matsushita, T., Kadomatsu, K., Nishimura, M., Muramatsu, T., Saito, H. Impact of antithrombin deficiency in thrombogenesis: lipopolysaccharide and stress-induced thrombus formation in heterozygous antithrombin-deficient mice. Blood 99, 2455-2458 (2002).
  313. Uchimura, K., El-Fasakhany, F. M., Hori, M., Hemmerich, S., Blink, S. E., Kansas, G. S., Kanamori, A., Kumamoto, K., Kannagi, R., Muramatsu, T. Specificities of N-acetylglucosamine-6-O-sulfotransferases in relation to L-selectin ligand synthesis and tumor-associated enzyme expression. J. Biol. Chem. 277, 3979-3984 (2002).
  314. Takei, Y., Kadomatsu. K., Itoh, H., Sato, W., Nakazawa, K., Kubota, S., Muramatsu, T. 5′-, 3′-Inverted thymidine-modified antisense oligodeoxynucleotide targeting midkine: its application for cancer therapy. J. Biol. Chem. 277, 23800-23806 (2002).
  315. Sumi, Y., Muramatsu, H., Takei, Y., Hata, K., Ueda, M., Muramatsu, T. Midkine, a heparin-binding growth factor promotes growth and glycosaminoglycan synthesis of endothelial cells through its action on smooth muscle cells in an artificial blood vessel model. J. Cell Sci. 115, 2659-2667 (2002).
  316. Shibata, Y., Muramatsu, T., Hirai, M., Inui, T., Kimura, T., Saito, H., McCormick, L.M., Bu, G., Kadomatsu, K. Nuclear targeting by the growth factor midkine. Mol. Cell. Biol. 22, 6788-6796 (2002).
  317. Kanamori, A., Kojima, N., Uchimura, K., Muramatsu, T., Tamatani, T., Berndt, M.C., Kansas, G.S., Kannagi, R. Distinct sulfation requirements of selectins disclosed using cells that support rolling mediated by all three selectins under shear flow. L-selectin prefers carbohydrate 6-sulfation to tyrosine sulfation, whereas P-selectin does not. J. Biol. Chem. 277, 32578-32586 (2002).
  318. Matsuura, O., Kadomatsu, K., Takei, Y., Uchimura, K., Mimura, S., Watanabe, K., Muramatsu, T. Midkine expression is associated with postnatal development of the lungs. Cell Struct. Funct. 27,109-115 (2002).
  319. Ochrietor, J.D., Moroz, T.P., Clamp, M.F., Timmers, AM., Muramatsu, T., Linser, P.J. Inactivation of the Basigin gene impairs normal retinal development and maturation. Vision Res. 42, 447-453 (2002).
  320. Saxena, D.K., Oh-oka, T., Kadomatsu, K., Muramatus, T., Toshimori, K. Behaviour of a sperm surface transmembrane glycoprotein basigin during epididymal maturation and its role in fertilization in mice. Reproduction 123,435-444 (2002).
  321. Adachi, Y., Matsubara, S., Muramatsu, T., Curiel, D.T., Reynolds, P.N. Midkine promoter-based adenoviral suicide gene therapy to midkine-positive pediatric tumor. J. Pediatr. Surg. 37, 588-592 (2002).
  322. Yoshida, Y., Tomizawa, M., Bahar, R., Miyauchi, M., Yamaguchi, T., Saisho, H., Kadomatsu K., Muramatsu, T., Matsubara, S., Sakiyama S.,Tagawa, M. A promoter region of midkine gene can activate transcription of an exogenous suicide gene in human pancreatic cancer. Anticancer Res. 22, 117-120 (2002).
  323. Xiao, L. J., Diao, H.L., MA X.H., Ding, N.Z., Kadomatsu, K., Muramatsu, T., Yang, Z. M. Basigin expression and hormonal regulation in the rat uterus during the peri-implantation period. Reproduction 124, 219-225 (2002).
  324. Zou, P., Zou, K., Muramatsu, H., Ichihara-Tanaka, K., Habuchi, O., Ohtake, S., Ikematsu, S., Sakuma S., Muramatsu, T. Glycosaminoglycan structures required for strong binding to midkine, a heparin-binding growth factor. Glycobiology 13, 35-42 (2003).
  325. Philp, N.J., Ochrietor, J.D., Rudoy, C., Muramatsu, T., Linser, P.J. Loss of MCT1, MCT3, and MCT4 expression in the retinal pigment epithelium and neural retina of the 5A11/basigin-null mouse. Invest. Ophthalmol. Vis. Sci. 44, 1305-1311 (2003).
  326.  El-Fasakhany, F. M., Ichihara-Tanaka, K., Uchimura, K., Muramatsu T. N-Acetylglucosamine-6-0-sulfotransferase-1: production in the baculovirus system and its applications to the synthesis of a sulfated oligosaccharide and to the modification of oligosaccharides in fibrinogen. J. Biochem. 133, 287-293 (2003).
  327. Ikematsu, S., Okamoto, K., Yoshida, Y., Oda, M., Sugano-Nagano, H., Ashida, K., Kumai, H., Kadomatsu, K., Muramatsu, H., Muramatsu, T., Sakuma, S. High levels of urinary midkine in various cancer patients. Biochem. Biophys. Res. Commun. 306, 329-332 (2003).
  328. Shimizu, E., Hashimoto, K., Salama, R.H., Watanabe, H., Komatsu, N., Okamura, N., Koike, K., Shinoda, N., Nakazato, M., Kumakiri, C., Okada, S., Muramatsu, H., Muramatsu, T., Iyo, M. Two clusters of serum midkine levels in drug-naive patients with schizophrenia. Neurosci. Lett. 344, 95-98 (2003).
  329. Ikematsu, S., Nakagawara, A., Nakamura, Y., Sakuma, S., Wakai, K., Muramatsu, T., Kadomatsu, K. Correlation of elevated level of blood midkine with poor prognostic factors of human neuroblastomas. Br. J. Cancer 88, 1522-1526 (2003).
  330. Betsuyaku, T., Kadomatsu, K., Griffin, G.L., Muramatsu, T., Senior, R.M. Increased basigin in bleomycin-induced lung injury. Am. J. Respir. Cell Mol. Biol. 28, 600-606 (2003).
  331. Sakai, K., Sumi, Y., Muramatsu, H., Hata, K., Muramatsu, T., Ueda, M. Thrombospondin-1 promotes fibroblast-mediated collagen gel contraction caused by activation of latent transforming growth factor ?-1. J. Dermatol. Sci. 31, 99-109 (2003).
  332. Sakaguchi, N., Muramatsu, H., Ichihara-Tanaka, K., Maeda, N., Noda, M., Yamamoto, T., Michikawa, M., Ikematsu, S., Sakuma S., Muramatsu, T. Receptor-type protein tyrosine phosphatase ? as a component of the signaling receptor complex for midkine-dependent survival of embryonic neurons. Neurosci. Res. 45, 219-224 (2003).
  333.  Tomizawa, M., Yu, L., Wada, A., Tamaoki, T., Kadomatsu, K., Muramatsu, T., Matsubara, S., Watanabe, K., Ebara, M., Saisho, H., Sakiyama, S., Tagawa, M. A promoter region of the midkine gene that is frequently expressed in human hepatocellular carcinoma can activate a suicide gene as effectively as the ?-fetoprotein promoter. Br. J. Cancer 89, 1086-1090 (2003).
  334. Ochrietor, J.D., Moroz, T.P., van Ekeris, L., Clamp, M.F., Jefferson, S.C., deCarvalho, A.C., Fadool, J.M., Wistow, G., Muramatsu, T., Linser, P.J. Retina-specific expression of 5A11/Basigin-2, a member of the immunoglobulin gene superfamily. Invest. Ophthalmol. Vis. Sci. 44, 4086-4096 (2003).
  335. Shimada, H., Nabeya, Y., Tagawa, M., Okazumi, S., Matsubara, H., Kadomatsu, K., Muramatsu, T., Ikematsu, S., Sakuma, S., Ochiai, T. Preoperative serum midkine concentration is a prognostic marker for esophageal squamous cell carcinoma. Cancer Sci. 94, 628-632 (2003).
  336. Shimada, H., Nabeya, Y., Okazumi, S., Matsubara, H., Kadomatsu, K., Muramatsu, T., Ikematsu, S., Sakuma, S., Ochiai, T. Increased serum midkine concentration as a possible tumor marker in patients with superficial esophageal cancer. Oncol. Rep.10, 411-414 (2003).
  337. Yu, L., Ugai, S., O-Wang, J., Namba, M., Kadomatsu, K., Muramatsu, T., Matsubara, S., Sakiyama, S., Tagawa, M. Cell growth- and P53-dependent transcriptional activity of the midkine promoter confers suicide gene expression in tumor cells. Oncol. Rep. 10, 1301-1315 (2004).
  338. Kobayashi, H., Mitsui, T., Nomura, S., Ohno, Y., Kadomatsu, K., Muramatsu, T., Nagasaka, T., Mizutani, S. Expression of glucose transporter 4 (GLUT4) in the human pancreatic islet of Langerhans. Biochem. Biophys. Res. Commun. 314, 1121-1125 (2004).
  339. Maruyama, K., Muramatsu, H., Ishiguro, N., Muramatsu, T. Midkine, a heparin-binding growth factor, is fundamentally involved in pathogenesis of rheumatoid arthritis. Arthritis Rheum. 50, 1420-1429 (2004).
  340. Sakakima, H., Yoshida, Y., Kadomatsu, K., Yuzawa, Y., Matsuo, S., Muramatsu, T. Midkine expression in rat spinal motor neurons following sciatic nerve injury. Brain Res. Dev. Brain Res. 153, 251-260 (2004).
  341. Kawai, H., Sato, W., Yuzawa, Y., Kosugi, T., Matsuo, S., Takei, Y., Kadomatsu, K., Muramatsu, T. Lack of the growth factor midkine enhances survival against cisplatin-induced renal damage. Am. J. Pathol. 165, 1603-1612 (2004).
  342. Ochiai, K., Muramatsu, H., Yamamoto, S., Ando, H., Muramatsu, T. The role of midkine and pleiotrophin in liver regeneration. Liver Int. 24, 484-491 (2004).
  343. Muramatsu, H., Zou, P., Suzuki, H., Oda, Y., Chen, G.-Y., Sakaguchi, N., Sakuma, S., Maeda, N., Noda, M., Takada, Y., Muramatsu, T. ?4?1- and ?61-integrins are functional receptors for midkine, a heparin-binding growth factor. J. Cell Sci. 117, 5405-5415 (2004).
  344. Yu, L., Hamada, K., Namba, M., Kadomatsu, K., Muramatsu, T., Matsubara, S., Tagawa, M. Midkine promoter-driven suicide gene expression and -mediated adenovirus replication produced cytotoxic effects to immortalised and tumour cells. Eur. J Cancer  40, 1787-1794 (2004).
  345. Ohuchida, T., Okamoto, K., Akahane, K., Higure, A., Todoroki, H., Abe, Y., Kikuchi, M., Ikematsu, S., Muramatsu, T., Itoh, H.. Midkine protects hepatocellular carcinoma cells against TRAIL-mediated apoptosis through down-regulation of caspase-3 activity. Cancer 100, 2430-2436 (2004).
  346. Takei, Y., Kadomatsu, K., Yuzawa, Y., Matsuo, S., Muramatsu, T. A small interfering RNA targeting vascular endothelial growth factor as cancer therapeutics. Cancer Res. 64, 3365-3370 (2004).
  347. Yu, L., Yamamoto, N., Kadomatsu, K., Muramatsu, T., Matsubara, S., Sakiyama, S., Tagawa, M. Midkine promoter can mediate transcriptional activation of a fused suicide gene in a broader range of human breast cancer compared with c-erbB-2 promoter. Oncology 66,143-149 (2004).
  348. Sakakima, H., Yoshida, Y., Muramatsu, T., Yone, K., Goto, M., Ijiri, K., Izumo, S.　Traumatic injury-induced midkine expression in the adult rat spinal cord during the early stage. J. Neurotrauma 21, 471-477 (2004).
  349. Inoh, K., Muramatsu, H., Ochiai, K., Torii, S., Muramatsu, T. Midkine, a heparin-binding cytokine, plays key roles in intraperitoneal adhesions. Biochem. Biophys. Res. Commun. 317, 108-113 (2004).
  350. Suzuki, N., Shibata, Y., Urano, T., Murohara, T., Muramatsu, T., Kadomatsu, K. Proteasomal degradation of the nuclear targeting growth factor midkine. J. Biol. Chem.  279, 17785-17791 (2004).
  351. Yu, L., Hamada, K., Namba, M., Kadomatsu, K., Muramatsu, T., Matsubara, S., Tagawa, M.  Insertion of an exogenous promoter in the E1A regulatory region of adenovirus does not disturb viral replication despite reduced E1A transcription. Cancer Lett. 203, 51-57 (2004).
  352.  Kobayashi, H., Nomura, S., Mitui, T., Ito, T., Kuno, N., Ohno, Y., Kadomatsu, K., Muramatsu, T., Nagasaka, T., Mizutani, S. Tissue distribution of    placental leucine aminopeptidase/oxytocinase during mouse pregnancy. J. Histochem. Cytochem. 52, 113-121 (2004).
  353. Chen, G.-Y., Muramatsu, H., Ichihara-Tanaka, K., Muramatsu, T. ZEC, a zinc finger protein with novel binding specificity and transcription regulatory activity. Gene 340, 71-81 (2004).
  354. Chen, S., Kadomatsu, K., Kondo, M., Toyama, Y., Toshimori, K., Ueno, S., Miyake, Y., Muramatsu, T. Effects of flanking genes on the phenotypes of mice deficient in basigin/CD147. Biochem. Biophys. Res. Commun. 32, 147-153 (2004).
  355. Chen, G.-Y., Muramatsu, H., Ichihara-Tanaka, K., Muramatsu, T. Expression profile of mouse BWF1, a protein with a BEACH domain, WD40 domain and FYVE domain. Cell  Struct. Funct. 29, 35-42 (2004).
  356. Miki, Y., Maruyama, S., Liu, D., Kobayashi, T., Sato, F., Shimizu, H., Kato, S., Sato, W., Morita, Y., Yuzawa, Y., Muramatsu, T., Matsuo, S. In vivo gene transfer of endo-β-galactosidase C removes αGal antigen on erythrocytes and endothelial cells of the organs. Xenotransplantation 11, 444-4451 (2004).
  357. Uchimura, K., Kadomatsu, K., El-Fasakhany, F.M., Singer, M.S., Izawa, M., Kannagi, R., Takeda, N., Rosen, S. D., Muramatsu, T. N-acetylglucosamine 6-O-sulfotransferase-1 regulates expression of L-selectin ligands and lymphocyte homing. J. Biol. Chem. 279, 35001-35008 (2004).
  358. Chang, H., Ni, H., Ma, X. H., Xu L.. B, Kadomatsu, K., Muramatsu, T., Yang, Z. M. Basigin expression and regulation in mouse ovary during the sexual maturation and development of corpus luteum. Mol. Reprod. Dev. 68, 135-141 (2004).
  359. Chen, L., Ichihara-Tanaka, K., Muramatsu, T. Role of the carboxyl-terminal region in the activity of N-acetylglucosamine 6-O-sulfotransferase-1. J. Biochem. 136, 659-664 (2004).
  360. Takei, Y., Kadomatsu, K., Yuasa, K., Sato, W., Muramatsu, T. Morpholino antisense oligomer targeting human midkine: Its application for cancer therapy. Int. J. Cancer  114, 490-497 (2005).
  361. Bao, X., Mikami, T., Yamada, S., Faissner, A., Muramatsu, T., Sugahara, K..  Heparin-binding growth factor, pleiotrophin, mediates neuritogenic activity of embryonic  pig brain-derived chondroitin sulfate/dermatan sulfate hybrid chains. J. Biol. Chem., 280,   9180-9191 (2005).
  362. Hayashi, K., Banno, H., Kadomatsu, K., Takei, Y., Komori, K., Muramatsu, T. Antisense
    oligodeoxyribonucleotide as to the growth factor midkine suppresses neointima formation induced by balloon injury. Am. J. Physiol. Heart Circ. Physiol. 288, H2203-2209 (2005).
  363. Obata, Y., Kikuchi, S., Lin, Y., Yagyu, K., Muramatsu, T., Kumai, H., Tokyo Research  Group on Prevention of Gastric Cancer. Serum midkine concentrations and gastric cancer. Cancer Sci., 54-56 (2005).
  364. Hirota, Y., Osuga, Y., Koga, K., Yoshino, O., Hirata, T., Harada, M., Morimoto, C., Yano,   T., Tsutsumi, O., Sakuma, S., Muramatsu, T., Taketani, Y. Possible implication of   midkine in the development of endometriosis. Hum Reprod. 20, 1084-1089 (2005).
  365. Takada, J., Ooboshi, H., Ago, T., Kitazono, T., Yao, H., Kadomatsu, K., Muramatsu, T.,   Ibayashi, S., Iida, M. Postischemic gene transfer of midkine, a neurotrophic factor, protects against focal brain ischemia. Gene Ther. 12, 487-493 (2005).
  366. Chen, G.Y., Muramatsu, H., Kondo, M., Kurosawa, N., Miyake, Y., Takeda, N., Muramatsu,   T. Abnormalities caused by carbohydrate alterations in Iβ6-N-acetylglucosaminyltransferase-deficient mice. Mol. Cell. Biol. 25, 7828-7838 (2005).
  367. Sato, W., Takei, Y., Yuzawa,Y., Matsuo, S., Kadomatsu, K., Muramatsu, T. Midkine antisense oligodeoxyribonucleotide inhibits renal damage induced by ischemic reperfusion.  Kidney Int. 67, 1330-1339 (2005).
  368. Yamamoto , S., Muramatsu, H., Muramatsu, T. Mutational studies on endo-β-N-acetylglucosaminidase D which hydrolyzes core portion of asparagine-linked complex type oligosaccharides. Glycoconj. J. 22, 35-42 (2005).
  369. Salama, R. H., Muramatsu, H., Shimizu, E., Hashimoto, K., Watanabe, H., Komatsu, N., Okumura, N., Koike, K., Shinoda, N., Okada, S., Iyo, M., Muramatsu, T. Increased midkine levels in sera from patients with Alzheimer’s disease. Prog. Neuropsychopharmacol. Biol.
    Psychiatry 29, 611-616 (2005).
  370. Uchimura, K., Gauguet, J. M., Singer, M. S., Tsay, D., Kannagi, R., Muramatsu, T., von    Andrian, U. H., Rosen, S. D. A major class of L-selectin ligands is eliminated in mice deficient in two sulfotransferases expressed in high endothelial venules.Nat. Immunol. 6,1105-1113 (2005).
  371. Kawashima, H., Petryniak, B., Hiraoka N., Mitoma, J., Huckaby, V., Nakayama, J., Uchimura, K., Kadomatsu, K., Muramatsu, T., Lowe, J.B., Fukuda, M. N-acetylglucosamine-6-O-sulfotransferases 1 and 2 cooperatively control lymphocyte homing through L-selectin ligand biosynthesis in high endothelial venules. Nat. Immunol. 6, 1096-1104 (2005).
  372. Bao, X., Muramatsu, T., Sugahara, K. Demonstration of the pleiotrophin-binding oligosaccharide sequences isolated from chondroitin sulfate/dermatan sulfate hybrid chains of embryonic pig brains. J. Biol. Chem. 280, 35318-35328 (2005).
  373. Salama, R. H., Muramatsu, H., Zou, P., Okayama, M., Muramatsu, T. Midkine, a  heparin-binding growth factor, produced by the host enhances metastasis of Lewis lung  carcinoma cells. Cancer Lett. 233, 16-20 (2006).
  374. Kosugi, T., Yuzawa, Y., Sato, W., Kawai, H., Matsuo, S., Takei, Y., Muramatsu, T., Kadomatsu, K. Growth factor midkine is involved in the pathogenesis of diabetic nephropathy. Am. J. Pathol. 168, 9-19 (2006).
  375. Zou, P., Muramatsu, H., Sone, M., Hayashi, H., Nakashima, T., Muramatsu, T. Mice
        doubly deficient in the midkine and pleiotrophin genes exhibit deficits in the expression of
        β-tectorin gene and in auditory response. Lab. Invest. 86, 645-653 (2006).
  376. Zhang, H., Muramatsu, T., Murase, A., Yuasa, S., Uchimura, K., Kadomatsu, K.                     N-acetylglucosamine 6-O-sulfotransferase-1 is required for brain keratan sulfate biosynthesis and glial scar formation after brain injury. Glycobiology 16, 702-710 (2006).
  377. Banno, H., Takei, Y., Muramatsu, T., Komori, K., Kadomatsu, K. Controlled release of small interfering RNA targeting midkine attenuates intimal hyperplasia in vein grafts. J. Vasc. Surg. 44, 633-641 (2006).
  378. Takei, Y., Kadomatsu, K., Goto, T., Muramatsu, T. Combinational antitumor effect of  siRNA against midkine and paclitaxel on growth of human prostate cancer xenografts. Cancer 107, 864-873 (2006).
  379. Ichihara-Tanaka, K., Oohira, A., Rumsby, M., Muramatsu, T. Neuroglycan C is a novel midkine receptor involved in process elongation of oligodendroglial precursor-like cells. J. Biol. Chem. 281, 30857-30864 (2006).
  380. Horiba, M., Kadomatsu, K., Yasui, K., Lee, J. K., Takenaka, H., Sumida, A., Kamiya, K.,   Chen, S., Sakuma, S., Muramatsu, T., Kodama, I. Midkine plays a protective role against cardiac ischemia/reperfusion injury through a reduction of apoptotic reaction. Circulation 114, 1713-20 (2006).
  381. Inoh, K., Muramatsu, H., Torii, S., Ikematsu, S., Oda, M., Kumai, H., Sakuma,  S., Inui, T., Kimura, T., Muramatsu, T.  Doxorubicin-conjugated anti-midkine monoclonal antibody as a potential anti-tumor drug. Jpn. J. Clin. Oncol.  36, 207-211 (2006).
  382. Yamamoto, H.  Muramatsu, H., Nakanishi, T., Natori, Y., Sakuma, S., Ishiguro, N.,  Muramatsu, T. Midkine as a molecular target: comparison of effects of chondroitin sulfate E and siRNA. Biochem. Biophys. Res. Commun., 351, 915-919 (2006).
  383. Muramatsu, H. Zou, P., Kurosawa, N., Ichihara-Tanaka, K., Maruyama, K., Inoh, K., Sakai, T., Chen, L., Sato, M., Muramatsu, T.  Female infertility in mice deficient in midkine and pleiotrophin, which form a distinct family of growth factors. Genes Cells. 11, 1405-1417 (2006).
  384. Zou, P., Muramatsu, H., Miyata, T., Muramatsu, T.  Midkine, a heparin-binding growth factor, is expressed on neural precursor cells and promotes their growth. J. Neurochem. 99, 1470-1479 (2006).
  385. Salama, R. H., Muramatsu, H., Kobayashi, H., Nomura, S., Mizutani, S.,        Muramatsu, T. Serum levels of midkine, a heparin-binding growth factor,  increase in both malignant and benign gynecological tumors. Reprod. Immunol. Biol. 21, 64-70 (2006).
  386. Bass, M.D., Roach, K.A., Morgan, M.R., Mostafavi-Pour, Z., Schoen, T., Muramatsu, T., Mayer U., Ballestrem, C, Spatz, J.P., Humphries, M.J. Syndecan-4-dependent Rac1 regulation determines directional migration in response to the extracellular matrix. J. Cell Biol. 177, 527-538 (2007).
  387. Hirota, Y., Osuga, Y., Nose, E., Koga, K., Yoshino, O., Hirota, T., Tsutsumi, O., Sakuma, S., Muramatsu, T., Taketani., Y.  The presence of midkine and its possible implication in human ovarian follicles.　Am. J. Reprod. Immunol. 58, 367-373 (2007).
  388. Whiteford, J.R., Behrends, V., Kirby, H., Kusche-Gullberg, M., Muramatsu, T., Couchman, J.R. Syndecans promote integrin-mediated adhesion of mesenchymal cells in two distinct pathways. Exp. Cell Res. 313, 3902-3913 (2007).
  389. Chen, S., Bu, G., Takei, Y., Sakamoto, K., Ikematsu, S., Muramatsu, T., Kadomatsu, K.
    Midkine and LDL-receptor-related protein 1 contribute to the anchorage-independent cell growth of cancer cells. J. Cell Sci. 120, 4009-4015 (2007).
  390. Watanabe, S., Misawa, M., Matsuzaki, T., Sakurai, T., Muramatsu, T., Yokomine, T.A., Sato, M. Production and characterization of transgenic mice systemically expressing endo-β-galactosidase C. Glycobiology 18, 9-19. (2007).
  391. Misawa, M., Watanabe, S., Ihara, S., Muramatsu, T., Matsuzaki, T. Accelerated proliferation and abnormal differentiation of epidermal keratinocytes in endo-β-galactosidase C transgenic mice. Glycobiology 18, 20-27 (2007).
  392. Aridome, K., Schurr, P. G., Reichelt, U., Wach0wiak, R., Yekebas, E. F., Mann, O., Ichihara-Tanaka, K., Muramatsu, T., Kluth, D., Strate, T., Izbicki, J. R. J. Cancer Res. Clin. Oncol. 133, 431-435 (2007).
  393. Muramatsu, H., Kusano, T., Sato, M., Oda, Y., Kobori, K., Muramatsu, T.
    Embryonic stem cells deficient in I β1,6-N-acetylglucosaminyltransferase exhibit reduced expression of embryoglycan and the loss of a Lewis X antigen, 4C9. Glycobiology 18, 242-249 (2008).
  394. Yoshida Y, Ikematsu S, Muramatsu H, Sakakima H, Mizuma N, Matsuda F, Sonoda K, Umehara F, Ohkubo R, Matsuura E, Goto M, Osame M, Muramatsu T. Expression of the heparin-binding growth factor midkine in the cerebrospinal fluid of patients with neurological disorders. Intern. Med. 47, 83-89 (2008).
  395. Takei Y, Nemoto T, Mu P, Fujishima T, Ishimoto T, Hayakawa Y, Yuzawa Y, Matsuo S, Muramatsu T, Kadomatsu K. In vivo silencing of a molecular target by short interfering RNA electroporation: tumor vascularization correlates to delivery efficiency. Mol. Cancer Ther. 211-221 (2008).
  396. Wang J, Takeuchi H, Sonobe Y, Jin S, Mizuno T, Miyakawa S, Fujiwara M, Nakamura Y, Kato T, Muramatsu H, Muramatsu T, Suzumura A. Inhibition of midkine alleviates experimental autoimmune encephalomyelitis through the expansion of regulatory T cell population. Proc. Natl. Acad. Sci. U S A. 105, 3915-3920 (2008).
  397. Fiegel, H. C., Kaifi, J. T., Wachowiak, R., Quaas, A., Aridome, K., Ichihara-Tanaka, K., Muramatsu, T., Metzger, R., Izbicki, J. R., Erttmann, R., Kluth, D., Till, H. Midkine is highly expressed in neuroblastoma tissues. Pediat. Surg. Int. 24, 1355-1359 (2008).
  398. Ohgake, S., Shimizu, E., Hashimoto, K., Okamura, N., Koike, K., Koizumi, H., Fujisaki, M., Kanahara, N., Matsuda, S., Sutoh, C., Matsuzawa, D.,  Muramatsu, H., Muramatsu, T., Iyo, M. Dopeminergic hypofunctions and prepulse inhibition deficits in mice lacking midkine. Prog. Neuropsychopharmacol. Biol. Psychiatry 33, 541-546 (2009).
  399. Scarpellini, A., Germack, R., Lortat-Jacob, H., Muramatsu, T., Billett, E., Johnson, T., Verderio, E. A. Heparan sulfate proteoglycans are rceptors for the cell-surface trafficking and biological activity of transglutaminase-2. J. Biol. Chem. 284, 18411-18423 (2009).
  400. Sakakima, H., Yoshida, Y., Yamazaki, Y., Matsuda, F., Ikutomo, M., Ijiri, K., Muramatsu, T., Muramatsu, H., Kadomatsu, K. Disruption of the midkine gene (Mdk) delays degeneration and regeneration in injured peripheral nerve. J. Neurosci. Res. 87, 2908-2915 (2009).

Reviews and Perspectives

  1. Nathenson, S.G., Shimada, A., Yamane, K., Muramatsu, T., Cullen, S., Mann, D.L., Fahey, J.L., Graff, R. Biochemical properties of papain-solubilized murine and human histocompatibility alloantigens. Fed. Proc. 29, 2026-2033 (1970).
  2. Muramatsu, T. Cell surface glycoproteins as markers in monitoring in vitro differentiation of embryonal carcinoma cells. Cell Differ. 15, 101-108 (1984).
  3.  Muramatsu, T. Developmentally regulated expression of cell surface carbohydrates during mouse embryogenesis. J. Cell. Biochem. 36, 1-14 (1988).
  4. Muramatsu, T. Alterations of cell-surface carbohydrates during differentiation and development. Biochimie 70, 1587-1596 (1988).
  5. Muramatsu, T. Les sucres de la membrane cellulaire. La Recherche 20, 624-634 (1989).
  6. Muramatsu, T. Retinoic acid regulates the expression of a new heparin binding growth differentiation factor. J. Nutr. Sci. Vitaminol. suppl., 485-487 (1992).
  7. Muramatsu, T. Midkine, the product of a retinoic acid responsive gene, and pleiotrophin constitute a new protein family regulating growth and differentiation. Int. J. Dev. Biol. 37, 183-188 (1993).
  8. Muramatsu, T. Carbohydrate signals in metastasis and prognosis of human carcinomas. Glycobiology 3, 291-296 (1993).
  9.  Muramatsu, T. The midkine family of growth differentiation factors. Dev. Growth Differ. 36, 1-8 (1994).
  10. Muramatsu, T. Cell surface glycoproteins: Biochemical, immunological and molecular biological studies. Nagoya J. Med. Sci. 57, 95-108 (1994).
  11. Muramatsu, T. Essential roles of carbohydrate signals in developmet, immune response and tissue functions, as revealed by gene targeting. J. Biochem. 127,171-176 (2000).
  12.  Muramatsu, T. Protein-bound carbohydrates on cell-surface as targets of recognition: an Odyssey in understanding them. Glycoconj. J. 17, 577-595 (2000).
  13. Muramatsu, T. Roles of proteoglycans in reception of midkine signal. Trends Glycosci. Glycotech. 13, 563-572 (2001).
  14. Muramatsu, T. Midkine and pleiotrophin: two related proteins involved in development, survival, inflammation and tumorigenesis. J. Biochem. 132, 359-371 (2002).
  15. Muramatsu, T., Miyauchi, T. Basigin (CD147): a multifunctional transmembrane protein involved in reproduction, neural function, inflammation and tumor invasion. Histol. Histopathol. 18, 981-987 (2003).
  16. Kadomatsu, K., Muramatus, T. Midkine and pleiotrophin in neural development and cancer. Cancer Lett. , 204, 127-143 (2004).
  17. Muramatsu, T., Muramatsu, H. Carbohydrate antigens expressed on stem cells and early embryonic cells. Glycoconj. J. 21, 41-45 (2004).
  18. Muramatsu, T., Muramatsu, H. Glycosaminoglycan-binding cytokines as tumor markers. Proteomics 8, 3350-3359 (2008)
  19. Muramatsu, T., Muramatsu, H. Carbohydrate Markers of ES cells. Trends Glycosci. Glycotech. 21, 197-206 (2009)

BOOKS

A Single-Authored Book

  • Muramatsu, T. Cell Surface and Differentiation. Chapman and Hall, London (1990).

Editions

  1.  Muramatsu, T., Gachelin G., Moscona, A.A., Ikawa, Y. Eds. Teratocarcinoma and Embryonic Cell Interactions. Japan Scientific Societies Press / Academic Press, Tokyo and New York (1982).
  2. Ohyama, M., Muramatsu, T. Eds. Glycoconjugates in Medicine. Professional Postgraduate Services, Tokyo and New York (1988).
  3. Takahashi, N., Muramatsu, T. Eds. CRC Handbook of Endoglycosidases and Glycoamidases. CRC Press, Boca Raton, Ann Arbor, London (1992).